Pathogenesis of acute respiratory illness caused by human parainfluenza viruses.
Pathogenesis of acute respiratory illness caused by human parainfluenza viruses.
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DOI：
10.1016/j.coviro.2012.02.001
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发表时间：
2012-06
影响因子：
5.9
通讯作者：
Schmidt, Alexander C.
中科院分区：
文献类型：
--
作者：
Schomacker, Henrick;Schaap-Nutt, Anne;Collins, Peter L.;Schmidt, Alexander C.
人副流感病毒（HPIV）是一生中急性呼吸道疾病的常见原因。婴儿、儿童和免疫功能低下的人最有可能患上严重疾病。HPIV 1和HPIV 2是引起哮吼的最常见原因，而HPIV 3是细支气管炎和肺炎的常见原因。HPIV在呼吸道上皮细胞中高效复制，除非宿主严重免疫功能低下，否则不会全身扩散。分子研究已经描述了HPIV如何逃避和阻断细胞先天免疫应答以允许有效复制、局部传播和宿主间传播。使用离体人气道上皮的研究集中在病毒嗜性、细胞病理学和上皮炎症反应，阐明感染早期事件如何塑造适应性免疫反应和疾病结果。
Human parainfluenza viruses (HPIVs) are a common cause of acute respiratory illness throughout life. Infants, children, and the immunocompromised are the most likely to develop severe disease. HPIV1 and HPIV2 are best known to cause croup while HPIV3 is a common cause of bronchiolitis and pneumonia. HPIVs replicate productively in respiratory epithelial cells and do not spread systemically unless the host is severely immunocompromised. Molecular studies have delineated how HPIVs evade and block cellular innate immune responses to permit efficient replication, local spread, and host-to-host transmission. Studies using ex vivo human airway epithelium have focused on virus tropism, cellular pathology and the epithelial inflammatory response, elucidating how events early in infection shape the adaptive immune response and disease outcome.
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