The Ay allele at the agouti locus reduces the size and alters the shape of the mandible in mice.
The Ay allele at the agouti locus reduces the size and alters the shape of the mandible in mice.
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DOI：
10.2183/pjab.85.248
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Suto J
中科院分区：
文献类型：
--
作者：
Suto J
为了证实我之前的发现，在KK小鼠品系背景下，agouti位点的Ay等位基因减小了下颌骨的大小，从而改变了下颌骨的形状，我进一步研究了Ay等位基因在不同品系背景、DDD和B6下对下颌骨形态的影响。主成分分析结果显示，Ay小鼠（DDD-Ay和B6-Ay）的下颌骨明显小于相应的非Ay小鼠（DDD和B6）。判别分析和典型判别分析表明，大多数小鼠在各自品系中被正确分类，DDD （-Ay）和B6 （-Ay）之间未见误分类。结果证实，无论菌株背景如何，Ay等位基因都能减小下颌骨的大小并改变下颌骨的形状。然而，在一个品系内，Ay小鼠与相应的非Ay小鼠在下颌骨形态上的差异并不像这两个品系内在的差异那么大。讨论了Ay作用的可能机理。
To confirm my previous findings that the Ay allele at the agouti locus reduced the mandible size and therefore altered the mandible shape in a KK mouse strain background, I further investigated the effects of the Ay allele on mandible morphology on different strain backgrounds, DDD and B6. Principal component analysis revealed that the mandible was significantly smaller in Ay mice (DDD-Ay and B6-Ay) than in corresponding non-Ay mice (DDD and B6, respectively). Discriminant and canonical discriminant analyses revealed that most mice were classified correctly in their own strains, and misclassification was not observed between DDD (-Ay) and B6 (-Ay). The results confirmed that the Ay allele reduced the mandible size and altered the mandible shape regardless of the strain background. However, the difference in mandible morphology between Ay mice and the corresponding non-Ay mice within a strain was not as large as that which intrinsically underlay the two strains. Possible mechanisms of the Ay action are discussed.
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影响因子：
9.2
作者：
Richman, J;Mitchell, PJ
通讯作者：
Mitchell, PJ
影响因子：
64.5
作者：
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
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DOI：
10.1017/s0016672300013306
发表时间：
1973-01-01
期刊：
GENETICAL RESEARCH
影响因子：
--
作者：
FESTING, M
通讯作者：
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影响因子：
64.8
作者：
FESTING, M
通讯作者：
FESTING, M