The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.
The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.
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DOI：
10.7150/ijbs.4262
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发表时间：
2012
影响因子：
9.2
通讯作者：
Cooley ID
中科院分区：
文献类型：
--
作者：
Arthur ST;Cooley ID
与年龄相关的骨骼肌质量和功能损失与肌肉减少症相关，可导致最终后果，如生活质量下降。肌肉减少症的原因是多因素的，包括环境和生物因素。这篇综述的目的是综合文献揭示的关于肌肉减少症的细胞调节，包括老年人肌肉再生能力受损，并讨论生理刺激是否有潜力减缓与肌肉减少症相关的生肌潜能的丧失。此外，这篇综述文章将讨论衰老对Notch和Wnt信号传导的影响，以及生理刺激是否有能力恢复Notch和Wnt信号传导，从而恢复衰老肌肉的修复。本总结的目的是使人们认识到一致的生理刺激（运动）对对抗肌肉减少症的益处，并宣布收缩诱导的损伤模型对研究局部和全身影响对老年生肌能力的影响的有用性。
The age-related loss of skeletal muscle mass and function that is associated with sarcopenia can result in ultimate consequences such as decreased quality of life. The causes of sarcopenia are multifactorial and include environmental and biological factors. The purpose of this review is to synthesize what the literature reveals in regards to the cellular regulation of sarcopenia, including impaired muscle regenerative capacity in the aged, and to discuss if physiological stimuli have the potential to slow the loss of myogenic potential that is associated with sarcopenia. In addition, this review article will discuss the effect of aging on Notch and Wnt signaling, and whether physiological stimuli have the ability to restore Notch and Wnt signaling resulting in rejuvenated aged muscle repair. The intention of this summary is to bring awareness to the benefits of consistent physiological stimulus (exercise) to combating sarcopenia as well as proclaiming the usefulness of contraction-induced injury models to studying the effects of local and systemic influences on aged myogenic capability.
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