Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder.
Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder.
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DOI：
10.1186/s11689-018-9244-y
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发表时间：
2018-08-30
影响因子：
4.9
通讯作者：
Webb SJ
中科院分区：
文献类型：
--
作者：
Naumann S;Senftleben U;Santhosh M;McPartland J;Webb SJ
已发现自闭症谱系障碍(ASD)患者的面部加工功能受损。一种假设是，与整体面孔处理策略相比，自闭症患者采用的是零碎的面孔处理策略。为了研究自闭症患者面部整体加工过程中可能的损伤所起的作用，目前的研究调查了患有自闭症的青少年和性别、年龄和智商匹配的神经典型对照的面部加工(P1/N170和伽马频段活动)的行为和脑电(EEG)的相关性。参与者被呈现了正反两种门尼刺激；黑白低信息面孔，只有在整体处理时才被感知为面孔。参与者在行为上表明了对脸部的检测。脑电采集的时间锁定到刺激的呈现。患有自闭症的青少年将门尼刺激视为面孔，这表明他们有能力使用整体加工，但表现出较低的面孔检测率和较慢的反应时间。事件相关电位成分显示，与对照组相比，自闭症患者对门尼刺激的时间加工在P1潜伏期有所减慢，但在P1波幅和N170时，两组之间没有差异。在各组感知门尼图像期间，伽马频段活动的增加是相似的，但ASD组显示出更长时间的活动增加。总体而言，我们的结果表明，大多数患有ASD的青少年能够利用整体加工来感知门尼刺激中的面孔。早期加工的延迟，以P1为标志，以及伽马活动的拉长上升，表明支持整体加工的神经系统略有改变，这表明面部处理系统自动化程度较低，效率较低。不适用。本文的在线版本(10.1186/s116890189244-y)包含补充材料，授权用户可以使用。
Face processing has been found to be impaired in autism spectrum disorders (ASD). One hypothesis is that individuals with ASD engage in piecemeal compared to holistic face processing strategies. To investigate the role of possible impairments in holistic face processing in individuals with autism, the current study investigated behavioral and electroencephalography (EEG) correlates of face processing (P1/N170 and gamma-band activity) in adolescents with ASD and sex-, age-, and IQ-matched neurotypical controls. Participants were presented with upright and inverted Mooney stimuli; black and white low information faces that are only perceived as faces when processed holistically. Participants indicated behaviorally the detection of a face. EEG was collected time-locked to the presentation of the stimuli. Adolescents with ASD perceived Mooney stimuli as faces suggesting ability to use holistic processing but displayed a lower face detection rate and slower response times. ERP components suggest slowed temporal processing of Mooney stimuli in the ASD compared to control group for P1 latency but no differences between groups for P1 amplitude and at the N170. Increases in gamma-band activity was similar during the perception of the Mooney images by group, but the ASD group showed prolonged temporal elevation in activity. Overall, our results suggest that adolescents with ASD were able to utilize holistic processing to perceive a face within the Mooney stimuli. Delays in early processing, marked by the P1, and elongated elevation in gamma activity indicate that the neural systems supporting holistic processing are slightly altered suggesting a less automatic and less efficient facial processing system. Non-applicable. The online version of this article (10.1186/s11689-018-9244-y) contains supplementary material, which is available to authorized users.
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