Why primate models matter.

Why primate models matter.
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DOI:
10.1002/ajp.22281
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发表时间:
2014-09
影响因子:
2.4
通讯作者:
Voytko, Mary Lou
Voytko, Mary Lou
中科院分区:
生物学3区
文献类型:
--
作者:
Phillips, Kimberley A.;Bales, Karen L.;Capitanio, John P.;Conley, Alan;Czoty, Paul W.;'t Hart, Bert A.;Hopkins, William D.;Hu, Shiu-Lok;Miller, Lisa A.;Nader, Michael A.;Nathanielsz, Peter W.;Rogers, Jeffrey;Shively, Carol A.;Voytko, Mary Lou

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涉及非人灵长类动物(NHP)的研究在过去世纪的许多医学和科学进步中发挥了至关重要的作用。使用NHPs是因为它们在生理学、神经解剖学、生殖、发育、认知和社会复杂性方面与人类相似,但正是这些相似性使得在生物医学研究中使用NHPs成为一个深思熟虑的决定。作为灵长类动物研究者,我们感到有义务和责任提出关于灵长类动物为什么被用于生物医学研究的各个领域的事实。美国最近做出的决定,包括国家卫生研究院在研究中逐步淘汰黑猩猩,以及新英格兰灵长类动物研究中心即将关闭,都向我们说明了传达为什么需要继续对灵长类动物进行研究的关键重要性。在这里,我们回顾了生物医学中的关键领域,灵长类动物模型已经并将继续是推进生物医学和生物学研究基础知识的关键。Am. J. Primatol. 76:801-827,2014.© 2014 Wiley Periodicals,Inc.
Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity—yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. Am. J. Primatol. 76:801–827, 2014. © 2014 Wiley Periodicals, Inc.
DOI: 10.1161/01.atv.10.6.1051
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