Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna.
Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna.
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运动疲劳损伤及相关骨定向重塑对大鼠尺骨的影响
DOI：
10.1186/s12938-017-0384-1
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发表时间：
2017-08-08
影响因子：
3.9
通讯作者：
Xi-Zheng Z
中科院分区：
文献类型：
--
作者：
Hao L;Rui-Xin L;Biao H;Bin Z;Bao-Hui H;Ying-Jie L;Xi-Zheng Z
由于长期剧烈的体力活动，长骨的疲劳损伤在跑步运动员和新兵中普遍存在。本研究试图了解运动性骨疲劳损伤的特点，并通过骨靶向重塑过程探讨疲劳损伤修复的机制。在INSTRON 5865型运动负荷仪上对Wistar大鼠右尺骨进行疲劳负荷，建立运动性疲劳损伤模型，并选取0、7、13、19天为实验时间点，分别模拟连续高强度训练的生理状态、初期、中期和常年阶段。对运动性疲劳载荷下大鼠尺骨的多层次响应进行了测试和统计分析，包括细胞蛋白表达、微观损伤或微裂纹以及宏观力学性能。Wistar大鼠在运动性疲劳负荷下，早期尺骨疲劳力学性能下降，骨吸收活跃，此后，骨形成活跃，尺骨疲劳力学性能明显改善。然而，准静态力学性能的恶化，在随后的时期意味着骨重建的限制，以保持长期剧烈运动期间的骨的承载能力。总之，运动疲劳负荷后，骨靶向重塑被激活并进行修复疲劳损伤，但仅在一定程度上。
Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process. Right ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i.e. experimental days: 0, 7, 13 and 19) were selected to simulate physiological status, preliminary, mid-term and perennial stage during continuous high-intensive training, respectively. The multi-level responses of rat ulnae under the athletic fatigue loading, including cellular protein expression, micro damage or micro-crack and macro mechanical properties, were tested and statistically analyzed. Wistar rats, subjected to the athletic fatigue loading protocol, experienced a decrease of ulna fatigue mechanical properties and an active bone resorption of the loaded ulnae in the early stage, whereafter, a hyperactive bone formation and significant improvements of ulnae fatigue mechanical properties were detected. However, a deterioration of quasi-static mechanical properties in the subsequent period implied limitations of bone remodeling to maintain the bearing capacity of bone during long-term strenuous exercise. In summary, after athletic fatigue loading, bone targeted remodeling is activated and proceeds to repair fatigue damage, but only to a certain extent.
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影响因子：
4.1
作者：
MORI, S;BURR, DB
通讯作者：
BURR, DB
影响因子：
2.4
作者：
Burger, EH;Klein-Nulend, J;Smit, TH
通讯作者：
Smit, TH
影响因子：
2.4
作者：
Haddock, SM;Yeh, OC;Keaveny, TM
通讯作者：
Keaveny, TM
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
6.2
作者：
Tomkinson, A;Gevers, EF;Noble, BS
通讯作者：
Noble, BS