Association of urinary caffeine and caffeine metabolites with cardiovascular disease risk in adults.
Association of urinary caffeine and caffeine metabolites with cardiovascular disease risk in adults.
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尿咖啡因和咖啡因代谢物与成人心血管疾病风险的关联。
DOI：
10.1016/j.nut.2020.111121
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发表时间：
2020
期刊：
影响因子：
4.4
通讯作者：
A. Gu
中科院分区：
文献类型：
--
作者：
Zhenkun Weng;Cheng Xu;Jin Xu;Zhaoyan Jiang;Qian Liu;Jingjia Liang;A. Gu
研究表明，适量的咖啡因摄入与降低心血管疾病（CVD）的风险有关，甚至可能对CVD有保护作用。本研究的目的是评估尿中咖啡因及其相关代谢物和心血管疾病的风险之间的关联，在美国adultes.MethodsWe的全国代表性样本从2009年和2010年的美国国家健康和营养检查调查的横截面数据进行分析。尿咖啡因代谢产物和自我报告的心血管疾病，包括充血性心力衰竭，冠心病，心绞痛，心脏病发作和中风的水平之间的关联，分别在男性和女性使用多变量logistic回归模型调整covariates.ResultsIn总数，1916名参与者（910名男性和1006名女性）被列入分析。在女性中，与最低四分位数相比，1，3-二甲基黄嘌呤和1，3，7-三甲基黄嘌呤最高四分位数的CVD比值比分别为0.33（95%置信区间[CI]，0.12-0.92）和0.35（95%CI，0.13-0.93）。在完全校正模型中，茶碱浓度每增加1个单位（µmol/L），高密度脂蛋白胆固醇增加0.24 mg/dL。在男性中，尿中咖啡因代谢物与CVD之间没有显著相关性。关于心血管疾病的亚型，与1，3-二甲基黄嘌呤和1，3，7-三甲基黄嘌呤最低四分位数的女性相比，冠心病的几率降低了90%（95% CI，−99%至−11%）和97%（95%CI，−99%至−47%），分别在最高四分位数的患者中。7-三甲基黄嘌呤与女性心血管疾病显著负相关。需要更多的研究来进一步证实本研究的结果并探讨其潜在机制。
ObjectivesStudies have shown that the consumption of a moderate amount of caffeine is associated with a reduced risk of cardiovascular disease (CVD) and may even be protective against CVD. The purpose of the current study was to evaluate the association between urinary caffeine and its related metabolites and CVD risk in a national representative sample of US adults.MethodsWe analyzed cross-sectional data from the US National Health and Nutrition Examination Survey from 2009 and 2010. The associations between the levels of urinary caffeine metabolites and self-reported CVD, including congestive heart failure, coronary heart disease, angina, heart attack, and stroke, were examined separately in men and women using multivariate logistic regression models adjusted for covariates.ResultsIn total, 1916 participants (910 men and 1006 women) were included in the analysis. Among women, the odds ratios of CVD in the highest quartiles of 1,3-dimethylxanthine and 1,3,7-trimethylxanthine were 0.33 (95% confidence interval [CI], 0.12–0.92) and 0.35 (95% CI, 0.13–0.93), respectively, compared with the lowest quartiles. Each one-unit (µmol/L) increase in theophylline concentration was associated with a 0.24-mg/dL increase in high-density lipoprotein cholesterol in the fully adjusted model. Among men, no significant association was observed between urinary caffeine metabolites and CVD. Regarding the subtypes of CVD, compared with women in the lowest quartile for 1,3-dimethylxanthine and 1,3,7-trimethylxanthine, the odds of coronary heart disease decreased by 90% (95% CI, −99% to −11%) and 97% (95% CI, −99% to −47%), respectively, in those in the highest quartile.ConclusionsUrinary 1,3-dimethylxanthine and 1,3,7-trimethylxanthine were significantly and inversely associated with CVDs in women. Additional studies are needed to further confirm the results of this study and explore the underlying mechanisms.
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影响因子：
11.8
作者：
Alshaarawy O;Elbaz HA;Andrew ME
通讯作者：
Andrew ME
DOI：
10.1016/j.bbadis.2017.01.020
发表时间：
2017-08
期刊：
Biochimica et biophysica acta. Molecular basis of disease
影响因子：
--
作者：
Rudomanova V;Blaxall BC
通讯作者：
Blaxall BC
DOI：
10.1016/s0002-9149(02)02405-0
发表时间：
2002-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Mendelsohn;R. Karas
通讯作者：
M. Mendelsohn;R. Karas
影响因子：
5
作者：
Ascherio, A;Weisskopf, MG;Thun, MJ
通讯作者：
Thun, MJ