Risk factors and biomarkers of ischemic stroke in cancer patients.
Risk factors and biomarkers of ischemic stroke in cancer patients.
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DOI：
10.5853/jos.2014.16.2.91
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发表时间：
2014-05
影响因子：
8.2
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Kim K;Lee JH
中风在癌症患者中很常见。然而，癌症患者中风的危险因素和生物标志物还没有很好地建立。本研究旨在探讨癌症患者缺血性卒中的危险因素和生物标志物以及病因学。对2003年1月至2012年12月期间在韩国釜山一家综合医院住院的缺血性卒中癌症患者进行了回顾性分析。将癌症患者中风和中风亚型的危险因素和生物标志物与同期入住同一医院的年龄和性别匹配的缺血性中风非癌症患者进行比较。确定了五十六例发生缺血性卒中的癌症患者。研究发现，与非癌症缺血性卒中患者相比，患有缺血性卒中的癌症患者患高血压、房颤、高脂血症和缺血性心脏病的比例显著降低。然而，卒中生物标志物，如红细胞沉降率和高敏C反应蛋白，纤维蛋白原，脑钠肽前体和D-二聚体水平，在癌症患者缺血性卒中比非癌症患者显着增加。大动脉粥样硬化和原因不明的卒中在癌症患者缺血性卒中中比在非癌症患者缺血性卒中中更常见。与非癌症缺血性卒中患者相比，癌症缺血性卒中患者显示出不同的危险因素、卒中生物标志物和卒中病因。
Stroke is common among cancer patients. However, risk factors and biomarkers of stroke in cancer patients are not well established. This study aimed to investigate risk factors and biomarkers as well as etiology of ischemic stroke in cancer patients. A retrospective review was conducted in cancer patients with ischemic stroke who were admitted to a general hospital in Busan, Korea, between January 2003 and December 2012. The risk factors and biomarkers for stroke and stroke subtypes in cancer patients were compared with age- and sex-matched noncancer patients with ischemic stroke who were admitted to the same hospital during the same period. One hundred fifty-six cancer patients with ischemic stroke were identified. Cancer patients with ischemic stroke were found to have a significantly lower proportion of hypertension, atrial fibrillation, hyperlipidemia, and ischemic heart disease than noncancer patients with ischemic stroke. However, stroke biomarkers, such as erythrocyte sedimentation rate and high-sensitivity C-reactive protein, fibrinogen, pro-brain natriuretic peptide, and D-dimer levels, were significantly increased in cancer patients with ischemic stroke than in noncancer patients. Large-artery atherosclerosis and stroke of undetermined cause were more common in cancer patients with ischemic stroke than in noncancer patients with ischemic stroke. Cancer patients with ischemic stroke showed different risk factors, stroke biomarkers, and stroke etiology compared with noncancer patients with ischemic stroke.
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DOI：
10.3988/jcn.2011.7.2.53
发表时间：
2011-06
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Bang OY;Seok JM;Kim SG;Hong JM;Kim HY;Lee J;Chung PW;Park KY;Kim GM;Chung CS;Lee KH
通讯作者：
Lee KH
影响因子：
5.8
作者：
Shishehbor, Mehdi H;Bhatt, Deepak L
通讯作者：
Bhatt, Deepak L
影响因子：
3.9
作者：
Kim, Jeong-Min;Jung, Keun-Hwa;Roh, Jae-Kyu
通讯作者：
Roh, Jae-Kyu
影响因子：
8.3
作者：
Kim, Seon Gyeong;Hong, Ji Man;Bang, Oh Young
通讯作者：
Bang, Oh Young
影响因子：
8.3
作者：
Schwarzbach, Christopher J.;Schaefer, Anke;Fatar, Marc
通讯作者：
Fatar, Marc