Protective role of gammadelta T cells in spontaneous ocular inflammation.
Protective role of gammadelta T cells in spontaneous ocular inflammation.
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DOI：
10.1167/iovs.08-2982
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发表时间：
2009-07
影响因子：
4.4
通讯作者：
Born WK
中科院分区：
文献类型：
--
作者：
O'Brien RL;Taylor MA;Hartley J;Nuhsbaum T;Dugan S;Lahmers K;Aydintug MK;Wands JM;Roark CL;Born WK
A role for γδ T cells in immunoregulation has been shown in a number of studies, but in the absence of infection or induced disease, mice lacking γδ T cells generally appear to be healthy. However, we report here that certain mice lacking γδ T cells often spontaneously develop keratitis, characterized by a progressive and destructive inflammation of the cornea. The keratitis developing in these mice was characterized in terms of prevalence in males vs. females, age of onset, and histological features. Attempts were made to understand the underlying causes of the disease by removing αβ T cells, altering sex hormones, and reconstituting γδ T cells. The development of keratitis in these mice depends upon the C57BL/10 genetic background, and is much more common among females than males. The incidence of the disease increases with age, exceeding 80% in females greater than 18 weeks old. We present evidence that the keratitis in these mice is at least partly autoimmune in nature, and that despite its prevalence in females, male hormones do not protect against the disease. These findings indicate an important role for γδ T cells in maintaining immune balance in the eye. The mice described in this study represent a potential new small animal model of keratitis.
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影响因子：
4.4
作者：
Huber, SA;Graveline, D;O'Brien, RL
通讯作者：
O'Brien, RL
影响因子：
4.4
作者：
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影响因子：
7.3
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影响因子：
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作者：
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通讯作者：
HERZENBERG, LA
影响因子：
2.8
作者：
Chikama, Tai-ichiro;Wakuta, Makiko;Nishida, Teruo
通讯作者：
Nishida, Teruo