Influence of Pre-treatment Saliva Microbial Diversity and Composition on Nasopharyngeal Carcinoma Prognosis.
Influence of Pre-treatment Saliva Microbial Diversity and Composition on Nasopharyngeal Carcinoma Prognosis.
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DOI：
10.3389/fcimb.2022.831409
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发表时间：
2022
影响因子：
5.7
通讯作者：
Ye W
中科院分区：
文献类型：
--
作者：
Du Y;Feng R;Chang ET;Debelius JW;Yin L;Xu M;Huang T;Zhou X;Xiao X;Li Y;Liao J;Zheng Y;Huang G;Adami HO;Zhang Z;Cai Y;Ye W
据报道，人类微生物组可以介导抗癌疗法的反应。然而，关于口腔微生物组对鼻咽癌（NPC）生存影响的研究尚缺乏。我们的目的是探讨口腔微生物群对鼻咽癌预后的影响。对 2010 年至 2013 年间中国南方地区 482 例人群的鼻咽癌病例进行了生存跟踪，并使用 16s rRNA 测序对他们的唾液样本进行了分析。我们分析了口腔微生物组多样性与全因死亡率和鼻咽癌死亡率的关联。平均 5.29 年的随访显示，社区内和社区间唾液的多样性与死亡率相关。与中等多样性相比，Lower Faith 的系统发育多样性与较高的全因死亡率 [调整后风险比 (aHR)，1.52（95% 置信区间 (CI)，1.06–2.17)] 和 NPC 特异性死亡率 [aHR，1.57（95% CI，1.07–2.29）] 相关，但较高的系统发育多样性并不能起到保护作用。从布雷-柯蒂斯距离主坐标分析 (PCoA) 确定的第三主坐标 (PC3) 与全因死亡率降低略有相关 [aHR, 0.85 (95% CI, 0.73–1.00)]，加权 UniFrac 上 PCoA 的第一个主坐标 (PC1) [aHR, 0.86 (95% CI, 0.74–1.00)]，但两者均不相关具有 NPC 特异性死亡率。稳健主成分分析得出的 PC3 与较低的全因死亡率和鼻咽癌特异性死亡率相关，HR 分别为 0.72（95% CI，0.61-0.85）和 0.71（95% CI，0.60-0.85）。口腔微生物组可能是鼻咽癌预后的一个解释因素。社区内多样性较低与死亡率较高相关，而社区间多样性的某些衡量指标也与死亡率相关。具体来说，候选细菌与死亡率无关，这表明观察到的关联可能是由于整体模式而不是特定病原体。
The human microbiome has been reported to mediate the response to anticancer therapies. However, research about the influence of the oral microbiome on nasopharyngeal carcinoma (NPC) survival is lacking. We aimed to explore the effect of oral microbiota on NPC prognosis. Four hundred eighty-two population-based NPC cases in southern China between 2010 and 2013 were followed for survival, and their saliva samples were profiled using 16s rRNA sequencing. We analyzed associations of the oral microbiome diversity with mortality from all causes and NPC. Within- and between-community diversities of saliva were associated with mortality with an average of 5.29 years follow-up. Lower Faith’s phylogenetic diversity was related to higher all-cause mortality [adjusted hazard ratio (aHR), 1.52 (95% confidence interval (CI), 1.06–2.17)] and NPC-specific mortality [aHR, 1.57 (95% CI, 1.07–2.29)], compared with medium diversity, but higher phylogenetic diversity was not protective. The third principal coordinate (PC3) identified from principal coordinates analysis (PCoA) on Bray–Curtis distance was marginally associated with reduced all-cause mortality [aHR, 0.85 (95% CI, 0.73–1.00)], as was the first principal coordinate (PC1) from PCoA on weighted UniFrac [aHR, 0.86 (95% CI, 0.74–1.00)], but neither was associated with NPC-specific mortality. PC3 from robust principal components analysis was associated with lower all-cause and NPC-specific mortalities, with HRs of 0.72 (95% CI, 0.61–0.85) and 0.71 (95% CI, 0.60–0.85), respectively. Oral microbiome may be an explanatory factor for NPC prognosis. Lower within-community diversity was associated with higher mortality, and certain measures of between-community diversity were related to mortality. Specifically, candidate bacteria were not related to mortality, suggesting that observed associations may be due to global patterns rather than particular pathogens.
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影响因子：
4.6
作者：
Chen YP;Zhao BC;Chen C;Lei XX;Shen LJ;Chen G;Yan F;Wang GN;Chen H;Jiang YQ;Xia YF
通讯作者：
Xia YF
影响因子：
15.5
作者：
Plantinga A;Zhan X;Zhao N;Chen J;Jenq RR;Wu MC
通讯作者：
Wu MC
影响因子：
6.4
作者：
Morton JT;Toran L;Edlund A;Metcalf JL;Lauber C;Knight R
通讯作者：
Knight R
影响因子：
--
作者：
Belstrøm D;Sembler-Møller ML;Grande MA;Kirkby N;Cotton SL;Paster BJ;Twetman S;Holmstrup P
通讯作者：
Holmstrup P
影响因子：
9.5
作者：
Hawinkel, Stijn;Mattiello, Federico;Thas, Olivier
通讯作者：
Thas, Olivier