Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria.
Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria.
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DOI：
10.1038/ncomms6921
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发表时间：
2015-01-06
影响因子：
16.6
通讯作者：
Christophides, George K.
中科院分区：
文献类型：
--
作者：
Gendrin, Mathilde;Rodgers, Faye H.;Yerbanga, Rakiswende S.;Ouedraogo, Jean Bosco;Basanez, Maria-Gloria;Cohuet, Anna;Christophides, George K.
减少疟疾的最有效办法是控制病媒，从而使感染和传播疟疾风险高的人群免受蚊虫叮咬。在这里，我们将疟疾感染者血液中抗生素的存在确定为增加疾病传播的新风险。我们发现，摄入血液中的抗生素通过干扰肠道微生物群来增强冈比亚按蚊对疟疾感染的易感性。在半自然环境中，通过用自然感染恶性疟原虫的儿童的血液喂养蚊子，证实了这种效果。抗生素暴露还增加了蚊子的存活率和繁殖力，这是众所周知的，以增加矢量的能力。这些发现表明，在抗生素使用率高的地区，疟疾传播可能会加剧，而针对传染病的大规模药物管理计划的地区可能需要加强病媒控制。 传播疟疾的蚊子的肠道微生物群有助于昆虫抵抗寄生虫。在这里，Gendrin等人表明，摄入的人类血液中的抗生素改变了蚊子肠道微生物群，增加了昆虫的生存，繁殖力和对寄生虫的易感性。
Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are protected from mosquito bites. Here, we identify the presence of antibiotics in the blood of malaria-infected people as a new risk of increasing disease transmission. We show that antibiotics in ingested blood enhance the susceptibility of Anopheles gambiae mosquitoes to malaria infection by disturbing their gut microbiota. This effect is confirmed in a semi-natural setting by feeding mosquitoes with blood of children naturally infected with Plasmodium falciparum. Antibiotic exposure additionally increases mosquito survival and fecundity, which are known to augment vectorial capacity. These findings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and that regions targeted by mass drug administration programs against communicable diseases may necessitate increased vector control. The gut microbiota of malaria-transmitting mosquitoes contributes to the insects’ resistance to the parasite. Here, Gendrin et al. show that antibiotics in ingested human blood alter the mosquito gut microbiota and increase the insect’s survival, fecundity and susceptibility to the parasites.
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影响因子：
15.8
作者：
Delves M;Plouffe D;Scheurer C;Meister S;Wittlin S;Winzeler EA;Sinden RE;Leroy D
通讯作者：
Leroy D
影响因子：
6.7
作者：
Garver LS;Bahia AC;Das S;Souza-Neto JA;Shiao J;Dong Y;Dimopoulos G
通讯作者：
Dimopoulos G
影响因子：
4.6
作者：
Bando, Hironori;Okado, Kiyoshi;Guelbeogo, Wamdaogo M.;Badolo, Athanase;Aonuma, Hiroka;Nelson, Bryce;Fukumoto, Shinya;Xuan, Xuenan;Sagnon, N'Fale;Kanuka, Hirotaka
通讯作者：
Kanuka, Hirotaka
影响因子：
4
作者：
Churcher, Thomas S.;Blagborough, Andrew M.;Sinden, Robert E.
通讯作者：
Sinden, Robert E.
DOI：
10.1073/pnas.0610451104
发表时间：
2007-05-22
影响因子：
11.1
作者：
Favia, Guido;Ricci, Irene;Daffonchio, Daniele
通讯作者：
Daffonchio, Daniele