Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level.
Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level.
复制标题
用于单细胞水平快速抗生素敏感性测试 (AST) 的微流体系统
DOI：
10.1039/d0sc01353f
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发表时间：
2020-04-01
期刊：
影响因子：
8.4
通讯作者：
Li J
中科院分区：
文献类型：
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作者：
Zhang K;Qin S;Wu S;Liang Y;Li J
Infectious diseases caused by multidrug resistant (MDR) bacterial pathogens are impending threats to global health. Since delays in identifying drug resistance would significantly increase mortality, fast and accurate antibiotic susceptibility tests (ASTs) are critical for addressing the antibiotic resistance issue. However, the conventional methods for ASTs are always labor-intensive, imprecise, complex and slow (taking 2–3 days). To address these issues, some advanced microfluidic systems have been designed for rapid phenotypic and genotypic analysis of antibiotic resistance. This review highlights the recent development of microfluidics-based ASTs at the single-cell or single-molecule level for guiding antibiotic treatment decisions and predicting therapeutic outcomes. Recent developments of microfluidics-based antibiotic susceptibility tests (ASTs) at the single-cell or single-molecule level are summarized for guiding antibiotic treatment.
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影响因子：
3.7
作者：
Hage-Hülsmann J;Grünberger A;Thies S;Santiago-Schübel B;Klein AS;Pietruszka J;Binder D;Hilgers F;Domröse A;Drepper T;Kohlheyer D;Jaeger KE;Loeschcke A
通讯作者：
Loeschcke A
影响因子：
7.4
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通讯作者：
Whitesides, George M.
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Lee, Francesca
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16.6
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Ali, M. Monsur;Aguirre, Sergio D.;Li, Yingfu
通讯作者：
Li, Yingfu
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影响因子：
--
作者：
Frickmann H;Masanta WO;Zautner AE
通讯作者：
Zautner AE