Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD4+ or CD8+ T cells.
Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD4+ or CD8+ T cells.
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DOI：
10.1084/jem.173.3.755
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发表时间：
1991-03-01
期刊：
影响因子：
--
通讯作者：
Harmsen AG
中科院分区：
文献类型：
--
作者：
Hill JO;Harmsen AG
研究了T淋巴细胞亚群对新生隐球菌机会菌株肺内和全身耐药性的贡献。结果表明，C.当将新形式癌病毒引入正常小鼠的肺中时，其被破坏，但扩散到用抗体处理的小鼠的脑中，该抗体耗尽了它们的CD4+ T细胞。CD8+或CD4+ T细胞的耗尽损害了宿主从肺中清除酵母的能力。这些结果，连同观察到的CD8+ T细胞在CD4+ T细胞缺陷小鼠的肺中积聚，表明CD8+ T细胞在抵抗C.通过呼吸道获得的新生儿感染。
The contribution of T lymphocyte subpopulations to intrapulmonary and systemic resistance against an opportunistic strain of Cryptococcus neoformans was examined. It was found that C. neoformans was destroyed when introduced into the lungs of normal mice, but disseminated to the brains of mice treated with an antibody that depleted them of CD4+ T cells. Depletion of either CD8+ or CD4+ T cells impaired the ability of the host to clear the yeast from the lung. These results, together with the observation that CD8+ T cells accumulate in the lungs of CD4+ T cell-deficient mice, suggest that CD8+ T cells play an important role in resistance to C. neoformans infection acquired via the respiratory tract.
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影响因子：
56.9
作者：
HOFFMAN, SL;ISENBARGER, D;BALLOU, WR
通讯作者：
BALLOU, WR
影响因子：
39.2
作者：
ITESCU, S;BRANCATO, LJ;WINCHESTER, R
通讯作者：
WINCHESTER, R
影响因子：
3.1
作者：
MURPHY, JW;COZAD, GC
通讯作者：
COZAD, GC
影响因子：
39.2
作者：
KOVACS, JA;KOVACS, AA;MASUR, H
通讯作者：
MASUR, H
DOI：
10.1016/0090-1229(89)90162-1
发表时间：
1989-09-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
--
作者：
GHOBRIAL, RRM;BOUBLIK, M;AUCHINCLOSS, H
通讯作者：
AUCHINCLOSS, H