Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity.
Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity.
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有氧能力近交大鼠模型心血管调节的表型差异。
DOI：
10.1152/physiolgenomics.1999.1.2.63
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
DiCarlo,SE
中科院分区：
文献类型：
--
作者：
Koch,LG;Britton,SL;Barbato,JC;Rodenbaugh,DW;DiCarlo,SE
放大图片作者：Steven L.作者：布里顿Barbato，大卫W. Rodenbaugh和Stephen E. DiCarlo。有氧能力近交系大鼠模型中心血管调节的表型差异。生理学。基因组学63 -69，1999。-与哥本哈根（COP）品系的近交系大鼠相比，黑猩猩（DA）近交系大鼠具有上级有氧跑台运动能力。这种有氧能力的差异提供了一个模型，以探索这种性状变异的遗传基础。本研究评估了10只雄性COP近交系大鼠和10只雄性DA近交系大鼠之间的中间表型差异，这些差异可能导致品系之间有氧能力的差异。通过测量对自主神经拮抗剂的反应，在休息或运动期间评估了五个受神经调节的心血管变量。DA大鼠具有增强的自主神经功能，用于调节外周血流量和心输出量。具体地，与COP大鼠相比，在休息时，DA大鼠具有用于心率控制的显著更多的交感神经（123 ± 8对99 ± 7次/分钟）和副交感神经（35 ± 5对12 ± 3次/分钟）紧张度以及对血压的更多交感神经支持（70 ± 7对38 ± 6 mmHg）。在三个等级的跑台运动中，DA大鼠的血压（平均16%）和心率（平均4%）相对于COP大鼠更高。此外，与COP品系大鼠相比，DA大鼠的心脏重量/体重比高27%（3.63 ± 0.08 vs. 2.85 ± 0.07 g/kg）。所有这五个中间表型可以参与变量之间的DA和COP大鼠品系的跑步机跑步能力的差异的原因。
Koch, Lauren Gerard, Steven L. Britton, John C. Barbato, David W. Rodenbaugh, and Stephen E. DiCarlo.Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity.Physiol. Genomics63–69, 1999.—The Dark Aouti (DA) inbred strain of rats has superior aerobic treadmill running capacity compared with the Copenhagen (COP) strain of inbred rats. This difference in aerobic capacity provides a model to explore the genetic basis of variation in this trait. The present study evaluated intermediate phenotypic differences between 10 male COP inbred rats and 10 male DA inbred rats that might contribute to the difference in aerobic capacity between the strains. Five autonomically regulated cardiovascular variables were evaluated during rest or exercise by measuring the response to autonomic antagonists. The DA rat had enhanced autonomic function for the regulation of peripheral blood flow and cardiac output. Specifically, at rest the DA rats had significantly more sympathetic (123 ± 8 vs. 99 ± 7 beats/min) and parasympathetic (35 ± 5 vs. 12 ± 3 beats/min) tonus for heart rate control and more sympathetic support of blood pressure (70 ± 7 vs. 38 ± 6 mmHg) compared with the COP rats. During three graded levels of treadmill exercise the DA rats had higher blood pressures (16% on average) and higher heart rates (4% on average) relative to the COP rats. In addition, the DA rats had a 27% greater heart weight-to-body weight ratio compared with the COP strain of rats (3.63 ± 0.08 vs. 2.85 ± 0.07 g/kg). All five of these intermediate phenotypes could participate as variables causative of the difference in treadmill running capacity between the DA and COP strains of rats.
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DOI：
10.1016/0002-9149(85)91054-9
发表时间：
1985
期刊：
The American journal of cardiology
影响因子：
--
作者：
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DOI：
10.1152/ajpregu.1998.274.2.r510
发表时间：
1998-02-01
影响因子：
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影响因子：
3.3
作者：
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DOI：
10.1152/ajplegacy.1963.204.2.291
发表时间：
1963
期刊：
The American journal of physiology
影响因子：
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作者：
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影响因子：
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作者：
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