Proximity to pollution sources and risk of amphibian limb malformation.
Proximity to pollution sources and risk of amphibian limb malformation.
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DOI：
10.1289/ehp.7585
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发表时间：
2005-11
影响因子：
10.4
通讯作者：
Rabinowitz PM
中科院分区：
文献类型：
--
作者：
Taylor B;Skelly D;Demarchis LK;Slade MD;Galusha D;Rabinowitz PM
野生两栖动物群体肢体畸形的原因仍不清楚，即使这种情况的流行率明显增加可能对人类健康产生影响。很少有研究同时评估多次暴露对肢体畸形风险的影响。在对佛蒙特州42个湿地的5，264只海猪和蛙类的横断面调查中，我们评估了非创伤性肢体畸形的独立危险因素。非创伤性肢体畸形的发生率因部位而异，从0到10.2%不等。对子样本的分析未显示任何感染寄生虫Ribeiroia的证据。我们使用地理信息系统（GIS）的土地利用/土地覆盖数据，以验证研究湿地附近的土地利用的实地观察。在包括土地利用以及发育阶段、属和水质指标的多元逻辑回归模型中，接近农业用地与肢体畸形风险增加相关（比值比= 2.26; 95%置信区间，1.42-3.58; p < 0.001）。统计模型的总体判别力较高（C = 0.79）。这些研究结果从一个最大的系统调查，迄今提供支持的作用，化学毒物在两栖动物肢体畸形的发展，并证明了这个问题的流行病学方法的价值。
The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42–3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem.
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影响因子：
4.1
作者：
Ankley, GT;Tietge, JE;Diamond, SA
通讯作者：
Diamond, SA
影响因子：
3.8
作者：
Degitz, SJ;Holcombe, GW;Ankley, GT
通讯作者：
Ankley, GT
影响因子：
3.3
作者：
Fort, DJ;Rogers, RL;Rolland, R
通讯作者：
Rolland, R
影响因子：
10.4
作者：
Burkhart, JG;Ankley, G;Lucier, G
通讯作者：
Lucier, G
影响因子：
6.1
作者：
de Roos, AM;Leonardsson, K;Mittelbach, GG
通讯作者：
Mittelbach, GG