Protective effect of basic fibroblast growth factor on retinal injury induced by argon laser photocoagulation
Protective effect of basic fibroblast growth factor on retinal injury induced by argon laser photocoagulation
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碱性成纤维细胞生长因子对氩激光光凝所致视网膜损伤的保护作用
DOI：
10.1002/lapl.201010080
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发表时间：
2010-10
影响因子：
1.7
通讯作者：
中科院分区：
文献类型：
--
作者：
激光光凝治疗通常会因不可避免的激光引起的视网膜破坏而导致视力障碍的副作用而变得复杂。目前尚未发现治愈这种视网膜病的特效药。本研究的目的是观察bFGF对激光引起的视网膜损伤的神经保护作用。将龙猫兔分为三组，并在视网膜上产生氩激光损伤。然后通过球后注射分别给予bFGF或广泛使用的眼用制剂地塞米松或生理盐水。对视网膜病变进行组织学和形态测量评估，并通过ERG检查视功能。结果表明，bFGF 给药更好地保留了视网膜光感受器的形态，并显着缩小了病变面积。此外，bFGF 促进 ERG b 波振幅的恢复。然而，在用地塞米松治疗的兔子中，病变几乎没有显示出改善的变化。这是第一项研究 bFGF 作为激光光凝治疗中的治疗剂的潜在作用的研究。这些研究结果表明，bFGF 在视网膜中具有显着的神经保护特性，这种类型的神经保护可能在减少人类医源性激光引起的视网膜损伤方面具有临床意义。
Laser photocoagulation treatment is often complicated by a side effect of visual impairment, which is caused by the unavoidable laser-induced retinal destruction. At present no specific is found to cure this retinopathy. The aim of this study was to observe the neuroprotective effect of bFGF on laser-induced retinal injury. Chinchilla rabbits were divided into three groups and argon laser lesions were created in the retinas. Then bFGF or dexamethasone, a widely used ophthalmic preparation, or saline was given severally by retrobulbar injection. The retinal lesions were evaluated histologically and morphometrically, and visual function was examined by ERG. The results showed that bFGF administration better preserved morphology of retinal photoreceptors and significantly diminished the area of the lesions. Furthermore, bFGF promoted the restoration of the ERG b-wave amplitude. In rabbits treated with dexamethasone, however, the lesions showed almost no ameliorative changes. This is the first study to investigate the potential role of bFGF as a remedial agent in laser photocoagulation treatment. These findings suggest that bFGF has significant neuroprotective properties in the retina and this type of neuroprotection may be of clinical significance in reducing iatrogenic laser-induced retinal injuries in humans.
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影响因子：
1.2
作者：
A. Yusupov;S. Goncharov;I. D. Zalevskii;V. Paramonov;A. Kurkov
通讯作者：
A. Yusupov;S. Goncharov;I. D. Zalevskii;V. Paramonov;A. Kurkov
影响因子：
1.7
作者：
V. Czaika;A. Alborova;W. Sterry;J. Lademann;S. Koch
通讯作者：
V. Czaika;A. Alborova;W. Sterry;J. Lademann;S. Koch
影响因子：
1.7
作者：
Kotoku, Y.;Kato, J.;Ishihara, K.
通讯作者：
Ishihara, K.
影响因子：
4.4
作者：
Li, F;Cao, W;Anderson, RE
通讯作者：
Anderson, RE
DOI：
10.1097/iae.0b013e318042d32c
发表时间：
2007-09-01
影响因子：
3.3
作者：
Fong, Donald S.;Girach, Aniz;Boney, April
通讯作者：
Boney, April