Convergence of Innate and Adaptive Immunity during Human Aging.
Convergence of Innate and Adaptive Immunity during Human Aging.
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DOI：
10.3389/fimmu.2016.00445
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发表时间：
2016
影响因子：
7.3
通讯作者：
Akbar AN
中科院分区：
文献类型：
--
作者：
Pereira BI;Akbar AN
衰老与人类免疫系统的深刻变化有关，这种现象被称为免疫衰老。这种复杂的免疫重建影响适应性免疫系统，特别是CD8+T细胞亚群，导致终末分化T细胞的积累，这些T细胞可以以有限的增殖能力为代价迅速发挥其效应功能。在这篇综述中，我们将讨论证据表明，衰老的αβCD8+T细胞获得先天类T细胞的特征，并使用最近获得的NK细胞受体作为一种替代机制来介导快速效应功能。这些细胞同时失去了共刺激受体的表达，并表现出T细胞受体信号的减弱，这表明功能上偏离了抗原特异性的激活。衰老T细胞的先天功能和适应性功能的融合挑战了先天免疫系统和获得性免疫系统之间的经典划分。先天T细胞对于应激和肿瘤监测特别重要，我们建议这些细胞在衰老中发挥新的作用，在这种情况下，获得先天功能可能代表着对随着年龄增加的恶性肿瘤负担的有益适应，尽管它也可能带来更高的自身免疫性疾病的风险。
Aging is associated with profound changes in the human immune system, a phenomenon referred to as immunosenescence. This complex immune remodeling affects the adaptive immune system and the CD8+ T cell compartment in particular, leading to the accumulation of terminally differentiated T cells, which can rapidly exert their effector functions at the expenses of a limited proliferative potential. In this review, we will discuss evidence suggesting that senescent αβCD8+ T cells acquire the hallmarks of innate-like T cells and use recently acquired NK cell receptors as an alternative mechanism to mediate rapid effector functions. These cells concomitantly lose expression of co-stimulatory receptors and exhibit decreased T cell receptor signaling, suggesting a functional shift away from antigen-specific activation. The convergence of innate and adaptive features in senescent T cells challenges the classic division between innate and adaptive immune systems. Innate-like T cells are particularly important for stress and tumor surveillance, and we propose a new role for these cells in aging, where the acquisition of innate-like functions may represent a beneficial adaptation to an increased burden of malignancy with age, although it may also pose a higher risk of autoimmune disorders.
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DOI：
10.1084/jem.20031051
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berg RE;Crossley E;Murray S;Forman J
通讯作者：
Forman J
影响因子：
7.3
作者：
Chen G;Lustig A;Weng NP
通讯作者：
Weng NP
影响因子：
8.8
作者：
Chu T;Tyznik AJ;Roepke S;Berkley AM;Woodward-Davis A;Pattacini L;Bevan MJ;Zehn D;Prlic M
通讯作者：
Prlic M
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
2.6
作者：
Franceschetti, Marta;Pievani, Alice;Introna, Martino
通讯作者：
Introna, Martino