Couples motivational interviewing with mobile breathalysers to reduce alcohol use in South Africa: a pilot randomised controlled trial of Masibambisane.
Couples motivational interviewing with mobile breathalysers to reduce alcohol use in South Africa: a pilot randomised controlled trial of Masibambisane.
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在南非，用移动呼气测醉器对夫妇进行动机性访谈以减少酒精使用：一项马西班比塞的随机对照试验。
DOI：
10.1136/bmjopen-2023-083390
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发表时间：
2024-01-30
期刊：
影响因子：
2.9
通讯作者：
Conroy, Amy A.
中科院分区：
文献类型：
--
作者：
Msimango, Lindani;Butterfield, Rita;Starks, Tyrel J.;van Heerden, Alastair;Neilands, Torsten B.;Hahn, Judy A.;Chibi, Buyisile;Humphries, Hilton;Conroy, Amy A.
撒哈拉以南非洲艾滋病毒感染者大量饮酒可能阻碍艾滋病毒治疗方案的成功，影响在实现联合国艾滋病毒/艾滋病规划署目标方面取得进展。主要伴侣可以提供关键形式的社会支持，以减少酗酒，并可纳入动机访谈（MI）干预措施，以解决酗酒问题；然而，很少有研究对撒哈拉以南非洲地区携带艾滋病毒的夫妇进行心肌梗死干预。我们的目的是评估一种以夫妇为基础的MI干预的可行性和可接受性，该干预采用移动呼气测醉器技术，以减少南非受艾滋病毒影响的夫妇大量饮酒并改善艾滋病毒治疗结果。我们将采用一项三组随机对照试验来评估基于夫妇的MI （MI-only组）和结合移动呼气测醉器（MI-plus组）的有效性，以解决酒精使用和HIV结果，并与强化常规护理（对照组）进行比较。我们将招募年龄在18-49岁的异性恋夫妇，他们的主要关系至少6个月，其中至少有一方报告危险饮酒，并接受抗逆转录病毒治疗6个月。MI组和MI组的参与者都将参加三次人工咨询会议，MI +组的参与者将通过移动呼气测醉器获得血液酒精浓度水平的实时反馈。随机分配到对照组的夫妇将根据《南非抗逆转录病毒治疗临床指南》接受强化的常规护理。可行性和可接受性指标将进行描述性分析，探索性假设将通过考虑时间点和治疗组的回归模型进行检验。该研究已获得加州大学旧金山分校（HRPP；协议号21-35034）和人类科学研究委员会研究伦理委员会（REC：协议号1/27/20/21）的批准。我们将在地方社区会议、社区一级卫生聚会和以艾滋病毒和酒精使用为重点的会议上传播研究结果。NCT05756790。
Heavy alcohol use among people living with HIV in sub-Saharan Africa can hinder the success of HIV treatment programmes, impacting progress towards United Nations Programme on HIV/AIDS goals. Primary partners can provide critical forms of social support to reduce heavy drinking and could be included in motivational interviewing (MI) interventions to address heavy drinking; however, few studies have evaluated MI interventions for couples living with HIV in sub-Saharan Africa. We aim to evaluate the feasibility and acceptability of a couple-based MI intervention with mobile breathalyser technology to reduce heavy alcohol use and improve HIV treatment outcomes among HIV-affected couples in South Africa. We will employ a three-arm randomised controlled trial to assess the efficacy of couple-based MI (MI-only arm) and in conjunction with mobile breathalysers (MI-plus arm) to address alcohol use and HIV outcomes, as compared with enhanced usual care (control arm). We will enrol heterosexual couples aged 18–49 in a primary relationship for at least 6 months who have at least one partner reporting hazardous alcohol use and on antiretroviral therapy for 6 months. Participants in both MI arms will attend three manualised counselling sessions and those in the MI-plus arm will receive real-time feedback on blood alcohol concentration levels using a mobile breathalyser. Couples randomised in the control arm will receive enhanced usual care based on the South African ART Clinical Guidelines. Feasibility and acceptability indicators will be analysed descriptively, and exploratory hypotheses will be examined through regression models considering time points and treatment arms. The study was approved by the University of California, San Francisco (HRPP; protocol number 21-35034) and Human Sciences Research Council Research Ethics Committee (REC: protocol number 1/27/20/21). We will disseminate the results at local community meetings, community-level health gatherings and conferences focused on HIV and alcohol use. NCT05756790.
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