Kidney pericytes: roles in regeneration and fibrosis.
Kidney pericytes: roles in regeneration and fibrosis.
复制标题
DOI：
10.1016/j.semnephrol.2014.06.004
复制
发表时间：
2014-07
影响因子：
3.3
通讯作者：
Humphreys, Benjamin D.
中科院分区：
文献类型：
--
作者：
Kramann, Rafael;Humphreys, Benjamin D.
肾周细胞多年来一直被忽视，但最近它们已成为肾脏生物学和病理生理学中深入研究的细胞群。周细胞是支持脉管系统的基质细胞，周细胞的一个子集是间充质干细胞。据报道，在肾脏中，周细胞在血管生成、肾髓质和皮质血流的调节中发挥关键作用，并在肾纤维发生中充当间质肌成纤维细胞的祖细胞。它们通过不同的信号通路与内皮细胞相互作用，急性或慢性肾损伤后它们的激活和与毛细血管的分离可能对于驱动慢性肾脏疾病的进展至关重要。相比之下，在肾脏稳态期间，周细胞很可能充当局部干细胞群，补充衰老过程中丢失的分化间质细胞和血管细胞。这篇综述描述了周细胞的再生特性以及与纤维发生等病理生理条件的关系。
Renal pericytes have been neglected for many years, but recently they have become an intensively studied cell population in renal biology and pathophysiology. Pericytes are stromal cells that support vasculature, and a subset of pericytes are mesenchymal stem cells. In kidney, pericytes have been reported to play critical roles in angiogenesis, regulation of renal medullary and cortical blood flow, and serve as progenitors of interstitial myofibroblasts in renal fibrogenesis. They interact with endothelial cells through distinct signaling pathways and their activation and detachment from capillaries after acute or chronic kidney injury may be critical for driving chronic kidney disease progression. By contrast, during kidney homeostasis it is likely that pericytes serve as a local stem cell population that replenishes differentiated interstitial and vascular cells lost during aging. This review describes both the regenerative properties of pericytes as well as involvement in pathophysiologic conditions such as fibrogenesis.
登录
查看更多内容
影响因子：
19.6
作者：
Chen, Jun;Park, Hyeong-Cheon;Addabbo, Francesco;Ni, Jie;Pelger, Edward;Li, Houwei;Plotkin, Matthew;Goligorsky, Michael S.
通讯作者：
Goligorsky, Michael S.
影响因子：
37.8
作者：
Farrington-Rock, C;Crofts, NJ;Canfield, AE
通讯作者：
Canfield, AE
影响因子：
13.6
作者：
Babitt, Jodie L.;Lin, Herbert Y.
通讯作者：
Lin, Herbert Y.
影响因子：
15.9
作者：
Abramsson, A;Lindblom, P;Betsholtz, C
通讯作者：
Betsholtz, C
DOI：
10.1111/j.1749-6632.2009.04967.x
发表时间：
2009-01-01
期刊：
HEMATOPOIETIC STEM CELLS VII
影响因子：
--
作者：
Crisan, Mihaela;Chen, Chien-Wen;Peault, Bruno
通讯作者：
Peault, Bruno