Quality of life and symptom burden among myeloproliferative neoplasm patients: do symptoms impact quality of life?
Quality of life and symptom burden among myeloproliferative neoplasm patients: do symptoms impact quality of life?
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DOI：
10.1080/10428194.2018.1480768
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发表时间：
2019-03
影响因子：
2.6
通讯作者：
Dueck AC
中科院分区：
文献类型：
--
作者：
Langlais BT;Geyer H;Scherber R;Mesa RA;Dueck AC
骨髓增生性肿瘤(MPN)患者面临较高的疾病相关症状负担和生活质量(QOL)下降。这项分析评估了单个症状或症状之间的汇总措施对总体和MPN亚组内的QOL的影响程度。构建了四套简明的测量方法，以组标准化和患者个体化的方法评估症状的患病率和严重程度。在1,416名国际MPNS患者中，平均症状严重程度与患病率高度相关(P<；.001)。对生活质量影响最大的个人症状是缺乏活动(R2=0.29)、疲劳(R2=0.23)和抑郁(R2=0.23)。需要多个症状严重程度评分才能最好地预测QOL。患者级别的症状严重程度比考虑症状数量较少的组级别的严重程度更能预测患者的生活质量。至少有一个严重症状和有多个中等强度的症状是生活质量下降的有意义的预测。结果在不同疾病亚组之间高度一致。
Patients with myeloproliferative neoplasms (MPNs) are faced with high disease-related symptom burden and quality of life (QoL) decrements. This analysis assesses the extent to which individual symptoms or summary measures across symptoms impact QoL overall and within MPN subgroups. Four sets of summary measures were constructed assessing symptom prevalence and severity within group-standardized and patient-individualized approaches. Among 1,416 international patients with MPNs, mean symptom severity and prevalence were highly correlated (P <.001). Individual symptoms most impacting QoL were inactivity (R2 = 0.29), fatigue (R2 = 0.23), and depression (R2 = 0.23). Multiple symptom severity scores are needed to best predict QoL. Symptom severity at the patient-level is more predictive of QoL than severity at the group-level where a fewer number of symptoms are considered. Having at least one severe symptom and having multiple symptoms of moderate intensity are meaningfully predictive of QoL decrements. Results were highly consistent across disease subgroups.
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影响因子：
45.3
作者：
Emanuel, Robyn M.;Dueck, Amylou C.;Mesa, Ruben A.
通讯作者：
Mesa, Ruben A.
影响因子：
20.3
作者：
Tefferi, Ayalew;Cervantes, Francisco;Barosi, Giovanni
通讯作者：
Barosi, Giovanni
影响因子：
2.7
作者：
Mesa RA;Schwager S;Radia D;Cheville A;Hussein K;Niblack J;Pardanani AD;Steensma DP;Litzow MR;Rivera CE;Camoriano J;Verstovsek S;Sloan J;Harrison C;Kantarjian H;Tefferi A
通讯作者：
Tefferi A
影响因子：
20.3
作者：
Scherber, Robyn;Dueck, Amylou C.;Mesa, Ruben A.
通讯作者：
Mesa, Ruben A.
影响因子：
6.2
作者：
Mesa, Ruben A.;Niblack, Joyce;Tefferi, Ayalew
通讯作者：
Tefferi, Ayalew