Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19.
Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19.
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DOI：
10.3390/molecules25225346
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发表时间：
2020-11-16
期刊：
影响因子：
--
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Bae M;Kim H
低水平的微量营养素与病毒感染期间的不良临床结果相关。因此，为了最大限度地提高对感染的营养防御，对于有2019年冠状病毒病（COVID-19）风险或被诊断患有COVID-19的营养不良患者，每日补充维生素和微量元素可能是有益的。最近对COVID-19患者的研究表明，急性呼吸道感染患者明显缺乏维生素D和硒。维生素D改善了对病毒的物理屏障，并刺激了抗菌肽的产生。它可以通过减少炎性细胞因子的产生来防止细胞因子风暴。硒增强细胞毒性效应细胞的功能。此外，硒对于维持T细胞成熟和功能以及T细胞依赖性抗体的产生是重要的。维生素C被认为是一种抗病毒剂，因为它可以提高免疫力。服用维生素C通过减弱免疫反应的过度激活，提高了COVID-19患者的存活率。维生素C增加抗病毒细胞因子和自由基的形成，降低病毒产量。它还能减弱过度的炎症反应和免疫细胞的过度活化。在这篇简短的综述中，讨论了维生素C、维生素D和硒在免疫系统中与COVID-19相关的作用。
Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections. Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at risk of or diagnosed with coronavirus disease 2019 (COVID-19) may be beneficial. Recent studies on COVID-19 patients have shown that vitamin D and selenium deficiencies are evident in patients with acute respiratory tract infections. Vitamin D improves the physical barrier against viruses and stimulates the production of antimicrobial peptides. It may prevent cytokine storms by decreasing the production of inflammatory cytokines. Selenium enhances the function of cytotoxic effector cells. Furthermore, selenium is important for maintaining T cell maturation and functions, as well as for T cell-dependent antibody production. Vitamin C is considered an antiviral agent as it increases immunity. Administration of vitamin C increased the survival rate of COVID-19 patients by attenuating excessive activation of the immune response. Vitamin C increases antiviral cytokines and free radical formation, decreasing viral yield. It also attenuates excessive inflammatory responses and hyperactivation of immune cells. In this mini-review, the roles of vitamin C, vitamin D, and selenium in the immune system are discussed in relation to COVID-19.
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影响因子：
3.7
作者：
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