Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging.
Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging.
复制标题
DOI：
10.1007/s11357-023-00784-8
复制
发表时间：
2023-06
期刊：
影响因子：
5.6
通讯作者：
Hagg, Sara
中科院分区：
文献类型：
--
作者：
Tang, Bowen;Li, Xia;Wang, Yunzhang;Sjolander, Arvid;Johnell, Kristina;Thambisetty, Madhav;Ferrucci, Luigi;Reynolds, Chandra A.;Finkel, Deborah;Jylhava, Juulia;Pedersen, Nancy L.;Hagg, Sara
衰老是许多慢性病的主要风险因素。本研究旨在探讨降压、降脂、降糖药物对生物衰老的影响。我们包括了来自瑞典领养/双胞胎老龄化研究的672名参与者和2746名重复测量。自我报告的药物用途被归类为降糖、降压和降脂药物。共有12个生物老化的生物标记物(BA生物标记物)被纳入结果。条件广义估计方程用于个体条件性地估计药物对同一人在使用和不使用药物时BA生物标志物水平的影响。在模型中，调整了年龄、体重指数、吸烟状况、多次用药次数、血压、血糖水平和apoB/apoA比率作为协变量。总体而言，使用降压药与一个DNA甲基化年龄的降低有关(PCGrimage：β=−0.39，95%CI=−0.67至−0.12)。在研究药物亚类时，钙通道阻滞剂(CCB)与几个DNA甲基化年龄的降低有关(PCHorvathAge Beta=−1.28，95%CI=−2.34至−0.21；PCSkin与血液年龄Beta=−1.34，95%CI=−2.61至−0.07；PCPhenoAge Beta=−1.74，95%CI=−2.58至−0.89；机能生物学年龄(功能年龄指数β=−2.18，95%CI=−3.65~−0.71；脆弱指数β=−1.31，95%CI=−2.43~−0.18)。然而，其他药物亚类内的结果并不一致。钙通道阻滞剂可以减少BA生物标志物在表观遗传和功能水平上捕捉到的生物衰老。未来的研究有必要证实这些影响并了解其潜在的生物学机制。网上版载有补充材料，可在10.1007/s11357.023-00784-8查阅。
Aging is a major risk factor for many chronic diseases. This study aimed to examine the effects of antihypertensive, lipid-lowering, and antidiabetic drugs on biological aging. We included 672 participants and 2746 repeated measurements from the Swedish Adoption/Twin Study of Aging. Self-reported medicine uses were categorized into antidiabetic, antihypertensive, and lipid-lowering drugs. A total of 12 biomarkers for biological aging (BA biomarkers) were included as outcomes. Conditional generalized estimating equations were applied conditioning on individuals to estimate the drug effect on BA biomarker level within the same person when using or not using the drug. Chronological age, body mass index, smoking status, number of multiple medication uses, blood pressure, blood glucose level, and apoB/apoA ratio were adjusted for as covariates in the model. Overall, using antihypertensive drugs was associated with a decrease in one DNA-methylation age (PCGrimAge: beta = − 0.39, 95%CI = − 0.67 to − 0.12). When looking into drug subcategories, calcium channel blockers (CCBs) were associated with a decrease in several DNA-methylation ages (PCHorvathAge beta = − 1.28, 95%CI = − 2.34 to − 0.21; PCSkin&bloodAge beta = − 1.34, 95%CI = − 2.61 to − 0.07; PCPhenoAge beta = − 1.74, 95%CI = − 2.58 to − 0.89; PCGrimAge beta = − 0.57, 95%CI = − 0.96 to − 0.17) and in functional biological ages (functional age index beta = − 2.18, 95%CI = − 3.65 to − 0.71; frailty index beta = − 1.31, 95%CI = − 2.43 to − 0.18). However, the results within other drug subcategories were inconsistent. Calcium channel blockers may decrease biological aging captured by the BA biomarkers measured at epigenetic and functional level. Future studies are warranted to confirm these effects and understand the underlying biological mechanisms. The online version contains supplementary material available at 10.1007/s11357-023-00784-8.
登录
查看更多内容
影响因子：
14
作者：
Johnson, Michael L.;Parikh, Niraj;Morgan, Robert O.
通讯作者：
Morgan, Robert O.
DOI：
10.18632/aging.203115
发表时间：
2021-06-03
期刊：
Aging
影响因子：
--
作者：
Kho M;Wang YZ;Chaar D;Zhao W;Ratliff SM;Mosley TH;Peyser PA;Kardia SLR;Smith JA
通讯作者：
Smith JA
影响因子：
7.8
作者：
Fiorito G;Caini S;Palli D;Bendinelli B;Saieva C;Ermini I;Valentini V;Assedi M;Rizzolo P;Ambrogetti D;Ottini L;Masala G
通讯作者：
Masala G
影响因子：
1.9
作者：
Finkel, D;Pedersen, NL
通讯作者：
Pedersen, NL
影响因子：
168.9
作者：
Jick, H;Zornberg, GL;Drachman, DA
通讯作者：
Drachman, DA