Rapid and Low Cost Manufacturing of Cuff Electrodes.
Rapid and Low Cost Manufacturing of Cuff Electrodes.
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DOI：
10.3389/fnins.2021.628778
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发表时间：
2021
影响因子：
4.3
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Flavin MT;Paul MA;Lim AS;Abdulhamed S;Lissandrello CA;Ajemian R;Lin SJ;Han J
对于许多外周神经调节应用，袖带电极已成为将电流输送到目标组织体积的首选技术。虽然具有低空间选择性、具有纵向排列的触点的基本袖带可以通过相对简单的工艺生产，但更复杂的电极配置的制造通常需要熟练技术人员的迭代设计和洁净室制造。尽管存在制造袖带电极的简便方法，但其不一致的产品限制了其快速制造的采用。在本文中，我们报告了一种快速、低成本的制造工艺，用于在植入式周围神经袖带中形成电极接触图案。使用我们规定的激光切割机，设计人员可以呈现批次之间一致的精确接触几何形状。该方法通过使用硅树脂/炭黑 (CB) 复合电极来实现，该电极与其基材（管状硅树脂绝缘体）的图案表面集成。其产品的尺寸和功能可以进行调整，以适应各种神经直径和应用。在这项研究中，我们专门记录了用于急性植入大鼠坐骨神经的具有三个触点径向阵列的环极袖带的制造和评估。作为该方法的一部分，我们还详细介绍了植入式袖带电极的验证（电化学表征）和验证（电生理学评估）的协议。应用于我们的环极袖带电极，我们报告了良好的电气特性。此外，我们报告它再现了先前文献中描述的预期电生理行为。我们的生产不需要专门的设备或制造经验，而且相对于商用解决方案，我们的成本可以忽略不计。正如我们所证明的，由于该过程产生一致且精确的电极几何形状，因此我们认为它在快速制造中具有强大的优点。
For many peripheral neuro-modulation applications, the cuff electrode has become a preferred technology for delivering electrical current into targeted volumes of tissue. While basic cuffs with low spatial selectivity, having longitudinally arranged contacts, can be produced from relatively straightforward processes, the fabrication of more complex electrode configurations typically requires iterative design and clean-room fabrication with skilled technicians. Although facile methods for fabricating cuff electrodes exist, their inconsistent products have limited their adoption for rapid manufacturing. In this article, we report a fast, low-cost fabrication process for patterning of electrode contacts in an implantable peripheral nerve cuff. Using a laser cutter as we have prescribed, the designer can render precise contact geometries that are consistent between batches. This method is enabled by the use of silicone/carbon black (CB) composite electrodes, which integrate with the patterned surface of its substrate—tubular silicone insulation. The size and features of its products can be adapted to fit a wide range of nerve diameters and applications. In this study, we specifically documented the manufacturing and evaluation of circumpolar cuffs with radial arrays of three contacts for acute implantation on the rat sciatic nerve. As part of this method, we also detail protocols for verification—electrochemical characterization—and validation—electrophysiological evaluation—of implantable cuff electrodes. Applied to our circumpolar cuff electrode, we report favorable electrical characteristics. In addition, we report that it reproduces expected electrophysiological behaviors described in prior literature. No specialized equipment or fabrication experience was required in our production, and we encountered negligible costs relative to commercially available solutions. Since, as we demonstrate, this process generates consistent and precise electrode geometries, we propose that it has strong merits for use in rapid manufacturing.
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