Design, fabrication and evaluation of a conforming circumpolar peripheral nerve cuff electrode for acute experimental use.
Design, fabrication and evaluation of a conforming circumpolar peripheral nerve cuff electrode for acute experimental use.
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DOI：
10.1016/j.jneumeth.2010.12.020
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发表时间：
2011-03-15
影响因子：
3
通讯作者：
Bhadra, Narendra
中科院分区：
文献类型：
--
作者：
Foldes, Emily L.;Ackermann, D. Michael;Bhadra, Niloy;Kilgore, Kevin L.;Bhadra, Narendra
神经袖电极是基础和应用电神经生理学研究的主要工具，因其能够以低阈值实现良好的神经再生而受到推崇。我们描述了一种用于急性实验的新型环极周围神经电极的设计和制造方法。这种圆柱形袖式电极为任意数量的接触提供了大约270度的径向电极与神经接触，具有在急性神经准备中允许简单放置和移除的轮廓，并且设计用于调整圆柱形直径以确保与神经紧密配合。对于每个电极，电触点从25µm铂箔上切割成一个阵列，以保持它们在袖套内的相对位置。导线被焊接到每个预定的触点上。然后用有机硅弹性体对结构进行模压，然后将各个触点电隔离。最终电极弯曲成圆柱形，内径与预期目标神经的内径相对应。在成型和成形过程中，这些触点的位置得到了很好的保持，并且在制造过程中由于触点位移而导致的故障率非常低。在一个电极上进行了建立的电化学测量，以确定铂电极的预期行为，并测量电极对不同频率施加电压的阻抗。这些电极已成功地用于神经刺激，记录和传导阻滞在许多不同的急性动物实验中由几个研究者。
Nerve cuff electrodes are a principle tool of basic and applied electro-neurophysiology studies and are championed for their ability to achieve good nerve recruitment with low thresholds. We describe the design and method of fabrication for a novel circumpolar peripheral nerve electrode for acute experimental use. This cylindrical cuff-style electrode provides approximately 270 degrees of radial electrode contact with a nerve for each of an arbitrary number of contacts, has a profile that allows for simple placement and removal in an acute nerve preparation, and is designed for adjustment of the cylindrical diameter to ensure a close fit on the nerve. For each electrode, the electrical contacts were cut from 25 µm platinum foil as an array so as to maintain their positions relative to each other within the cuff. Lead wires were welded to each intended contact. The structure was then molded in silicone elastomer, after which the individual contacts were electrically isolated. The final electrode was curved into a cylindrical shape with an inner diameter corresponding to that of the intended target nerve. The positions of these contacts were well maintained during the molding and shaping process and failure rates during fabrication due to contact displacements were very low. Established electrochemical measurements were made on one electrode to confirm expected behavior for a platinum electrode and to measure the electrode impedance to applied voltages at different frequencies. These electrodes have been successfully used for nerve stimulation, recording, and conduction block in a number of different acute animal experiments by several investigators.
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影响因子：
2
作者：
Mariano, Timothy Y.;Bhadra, Narendra;Gustafson, Kenneth J.
通讯作者：
Gustafson, Kenneth J.
影响因子：
4.6
作者：
Franks, W;Schenker, I;Hierlemann, A
通讯作者：
Hierlemann, A
影响因子：
4.6
作者：
NAPLES, GG;MORTIMER, JT;SWEENEY, JD
通讯作者：
SWEENEY, JD
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
神经袖带电极几何形状对高频神经传导阻滞中起始反应放电的影响。
DOI：
10.1109/tnsre.2010.2071882
发表时间：
2010-12
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Ackermann DM Jr;Bhadra N;Foldes EL;Wang XF;Kilgore KL
通讯作者：
Kilgore KL