Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.
Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.
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DOI：
10.1002/hbm.23898
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Duke Neurologic Outcomes Research Group (NORG)
中科院分区：
文献类型：
--
作者：
Browndyke JN;Berger M;Smith PJ;Harshbarger TB;Monge ZA;Panchal V;Bisanar TL;Glower DD;Alexander JH;Cabeza R;Welsh-Bohmer K;Newman MF;Mathew JP;Duke Neurologic Outcomes Research Group (NORG)
Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and non-surgical controls. Older cardiac surgery patients (n=25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6-weeks after surgery; non-surgical controls with cardiac disease (n=26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group x time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA. Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p<0.001, cluster p-FWE<0.05). The dPCC also showed a postoperative increase in working memory load-associated local coherence (p<0.001, cluster p-FWE<0.05). dPCC degree centrality and local coherence increases were inversely associated with global cognitive change in surgery patients (p<0.01), but not in controls. Cardiac surgery patients showed postoperative increases in working memory load-associated degree centrality and local coherence of the dPCC that were inversely associated with postoperative global cognitive outcomes and independent of perioperative cerebrovascular damage.
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影响因子：
5.7
作者：
Constable, R. Todd;Vohr, Betty R.;Scheinost, Dustin;Benjamin, Jennifer R.;Fulbright, Robert K.;Lacadie, Cheryl;Schneider, Karen C.;Katz, Karol H.;Zhang, Heping;Papademetris, Xenophon;Ment, Laura R.
通讯作者：
Ment, Laura R.
DOI：
10.1080/13803395.2014.960370
发表时间：
2014
影响因子：
2.2
作者：
Casaletto KB;Cattie J;Franklin DR;Moore DJ;Woods SP;Grant I;Heaton RK;HNRP Group
通讯作者：
HNRP Group
老年人进行大型心脏手术后的静止状态功能连通性和认知，而没有术前认知障碍：初步发现。
影响因子：
6.3
作者：
Browndyke JN;Berger M;Harshbarger TB;Smith PJ;White W;Bisanar TL;Alexander JH;Gaca JG;Welsh-Bohmer K;Newman MF;Mathew JP
通讯作者：
Mathew JP
影响因子：
4.6
作者：
Cook, David J.;Huston, John, III;Sundt, Thoralf M., III
通讯作者：
Sundt, Thoralf M., III
DOI：
10.1111/j.1532-5415.2011.03676.x
发表时间：
2011-11-01
影响因子：
6.3
作者：
Campbell, Noll;Perkins, Anthony;Boustani, Malaz
通讯作者：
Boustani, Malaz