A left cerebellar pathway mediates language in prematurely-born young adults.
A left cerebellar pathway mediates language in prematurely-born young adults.
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DOI：
10.1016/j.neuroimage.2012.09.008
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发表时间：
2013-01-01
期刊：
影响因子：
5.7
通讯作者：
Ment, Laura R.
中科院分区：
文献类型：
--
作者：
Constable, R. Todd;Vohr, Betty R.;Scheinost, Dustin;Benjamin, Jennifer R.;Fulbright, Robert K.;Lacadie, Cheryl;Schneider, Karen C.;Katz, Karol H.;Zhang, Heping;Papademetris, Xenophon;Ment, Laura R.
关键词：
早产儿（PT）受试者有发育迟缓的风险，基于任务的研究表明，发育障碍可能是由于神经连接的改变。由于新出现的数据意味着在典型的发展语言习得的重要性，我们假设，PT科目将有替代领域的小脑连接，这些领域将负责PT科目和长期控制在20岁之间的认知结果的差异。19名PT和19名长期控制的年轻成年人进行了前瞻性研究，使用静息态功能MRI（fMRI）创建基于体素的对比图，反映了每个组织元素的功能连接，在灰质通过分析的内在连接对比度（ICC-d）。受试者之间的左小脑ICC-d差异确定了一个感兴趣的区域，用于随后的基于种子的连接性分析。受试者接受标准化语言测试，并评估与认知结果的相关性。在性别、用手偏好、母亲受教育程度、学习年龄或皮博迪图片词汇测试（PPVT）分数方面没有差异。功能连接性（FcMRI）显示，与足月对照组相比，PT中L小脑的二腹小叶、单小叶和四边形小叶的组织连接性增加（p<0.05）;这些区域的基于种子的分析显示，与足月对照组相比，PT中从L小脑到R和L额下回（IFG）的连接性改变。对于PT而不是术语对照，这些连接与PPVT评分（R IFG：r=0.555，p=0.01; L IFG：r=0.454，p=0.05）以及言语理解指数（VCI）评分（R IFG：r=0.472，p=0.04）之间存在显著正相关。这些数据表明，在PT受试者在年轻的成年期左侧小脑语言回路的存在。这些发现可能代表了发育中的PT大脑中语言的替代神经通路的成熟延迟或参与。
Preterm (PT) subjects are at risk for developmental delay, and task-based studies suggest that developmental disorders may be due to alterations in neural connectivity. Since emerging data imply the importance of right cerebellar function for language acquisition in typical development, we hypothesized that PT subjects would have alternate areas of cerebellar connectivity, and that these areas would be responsible for differences in cognitive outcomes between PT subjects and term controls at age 20 years. Nineteen PT and 19 term control young adults were prospectively studied using resting-state functional MRI (fMRI) to create voxel-based contrast maps reflecting the functional connectivity of each tissue element in the grey matter through analysis of the intrinsic connectivity contrast degree (ICC-d). Left cerebellar ICC-d differences between subjects identified a region of interest that was used for subsequent seed-based connectivity analyses. Subjects underwent standardized language testing, and correlations with cognitive outcomes were assessed. There were no differences in gender, hand preference, maternal education, age at study, or Peabody Picture Vocabulary Test (PPVT) scores. Functional connectivity (FcMRI) demonstrated increased tissue connectivity in the biventer, simple and quadrangular lobules of the L cerebellum (p<0.05) in PTs compared to term controls; seed-based analyses from these regions demonstrated alterations in connectivity from L cerebellum to both R and L inferior frontal gyri (IFG) in PTs compared to term controls. For PTs but not term controls, there were significant positive correlations between these connections and PPVT scores (R IFG: r=0.555, p=0.01; L IFG: r=0.454, p=0.05), as well as Verbal Comprehension Index (VCI) scores (R IFG: r=0.472, p=0.04). These data suggest the presence of a left cerebellar language circuit in PT subjects at young adulthood. These findings may represent either a delay in maturation or the engagement of alternative neural pathways for language in the developing PT brain.
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