Exercise induced adipokine changes and the metabolic syndrome.
Exercise induced adipokine changes and the metabolic syndrome.
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DOI：
10.1155/2014/726861
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发表时间：
2014
影响因子：
4.3
通讯作者：
Laher I
中科院分区：
文献类型：
--
作者：
Golbidi S;Laher I
缺乏足够的身体活动和肥胖症造成了世界范围的流行病。肥胖症的特征在于脂肪组织在身体的各个部位的沉积;现在很明显，脂肪组织还充当能够分泌许多细胞因子的内分泌器官，这些细胞因子被认为参与肥胖症、胰岛素抵抗和代谢综合征的病理生理学。脂肪因子，或脂肪组织衍生的蛋白质，在这种情况下发挥关键作用。促炎性脂肪因子分泌增加导致慢性炎症状态，伴随胰岛素抵抗和葡萄糖耐受不良。增加体力活动和锻炼方面的生活方式改变是肥胖症的最佳非药物治疗，因为这些可以降低胰岛素抵抗，抵消炎症状态，并改善血脂。越来越多的证据表明，运动发挥其有益的影响，部分通过改变脂肪因子的档案，即运动增加分泌的抗炎脂肪因子和减少促炎细胞因子。在本文中，我们简要描述了四个重要的脂肪因子（脂联素，瘦素，TNF-α和IL-6）在代谢综合征中的病理生理作用，并回顾了一些监测这些脂肪因子作为运动前后临床结果的临床试验。
The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.
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影响因子：
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