Use of camel single-domain antibodies for the diagnosis and treatment of zoonotic diseases.
Use of camel single-domain antibodies for the diagnosis and treatment of zoonotic diseases.
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DOI：
10.1016/j.cimid.2018.09.009
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Lafaye P;Li T
VHHs provide many advantages over complete IgG in diagnostics and therapy. Toxins and viruses are more efficiently neutralized by multivalent VHHs. Camelids could be a source of broadly neutralizing antibodies (bNAbs) to treat zoonotic diseases. Camelids produce both conventional heterotetrameric antibodies and homodimeric heavy-chain only antibodies. The antigen-binding region of such homodimeric heavy-chain only antibodies consists of one single domain, called VHH. VHHs provide many advantages over conventional full-sized antibodies and currently used antibody-based fragments (Fab, scFv), including high specificity, stability and solubility, and small size, allowing them to recognize unusual antigenic sites and deeply penetrate tissues. Since their discovery, VHHs have been used extensively in diagnostics and therapy. In recent decades, the number of outbreaks of diseases transmissible from animals to humans has been on the rise. In this review, we evaluate the status of VHHs as diagnostic and therapeutic biomolecular agents for the detection and treatment of zoonotic diseases, such as bacterial, parasitic, and viral zoonosis. VHHs show great adaptability to inhibit or neutralize pathogenic agents for the creation of multifunctional VHH-based diagnostic and therapeutic molecules against zoonotic diseases.
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影响因子：
10.8
作者：
Arias, Jose L.;Unciti-Broceta, Juan D.;Garcia-Salcedo, Jose A.
通讯作者：
Garcia-Salcedo, Jose A.
DOI：
10.3390/pathogens6030033
发表时间：
2017-07-21
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Helmy YA;El-Adawy H;Abdelwhab EM
通讯作者：
Abdelwhab EM
影响因子：
3.1
作者：
Atlas, R. M.
通讯作者：
Atlas, R. M.
影响因子：
3.7
作者：
Hultberg A;Temperton NJ;Rosseels V;Koenders M;Gonzalez-Pajuelo M;Schepens B;Ibañez LI;Vanlandschoot P;Schillemans J;Saunders M;Weiss RA;Saelens X;Melero JA;Verrips CT;Van Gucht S;de Haard HJ
通讯作者：
de Haard HJ
影响因子：
3.5
作者：
Ghahroudi, MA;Desmyter, A;Muyldermans, S
通讯作者：
Muyldermans, S