Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans.
Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans.
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DOI：
10.2967/jnumed.117.190546
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Symonds ME
中科院分区：
文献类型：
--
作者：
Law J;Morris DE;Izzi-Engbeaya C;Salem V;Coello C;Robinson L;Jayasinghe M;Scott R;Gunn R;Rabiner E;Tan T;Dhillo WS;Bloom S;Budge H;Symonds ME
肥胖及其代谢后果是发病率和死亡率的主要原因。棕色脂肪组织(BAT)利用葡萄糖和游离脂肪酸产生热量，从而增加能量消耗。对人类BAT刺激物的有效评估受到当前评估BAT的标准方法--PET/CT--的限制，因为它需要暴露在高剂量的电离辐射中。红外热像仪(IRT)是一种潜在的无创、安全的替代方法，尽管与PET/CT的直接确证尚未建立。方法：对8例健康男性水套降温患者的IRT和18F-FDG PET/CT图像进行对比分析。将热像几何变换为每个受试者的PET/CT最大密度投影(MIP)图像，并比较锁骨上区域内温度和葡萄糖摄取最强的区域。测定IRT测得的锁骨上温度(TSCR)与PET/CT测得的葡萄糖摄取率(MR(Gluc))之间的关系。结果：MR(Gluc)MIP上的葡萄糖摄取与TScr相对于参考区的变化呈正相关(R2=0.721；P=0.008)。最大MR(Gluc)MIP和最大TSCR之间的空间重叠为29.5%±5.1%。与降温10分钟相比，延长降温60分钟与进一步升高TSCR有关。结论：IRT显示的锁骨上热点与PET/CT MR(Gluc)MIP图像上的最大摄取区域密切对应。相对TScr的较大增加与葡萄糖摄取增加有关。IRT现在应该被认为是测量BAT激活的合适方法，特别是在PET/CT对其不可行、实用或可重复的人群中。
Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilizes glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by the current standard method of assessing BAT—PET/CT—as it requires exposure to high doses of ionizing radiation. Infrared thermography (IRT) is a potential noninvasive, safe alternative, although direct corroboration with PET/CT has not been established. Methods: IRT and 18F-FDG PET/CT data from 8 healthy men subjected to water-jacket cooling were directly compared. Thermal images were geometrically transformed to overlay PET/CT-derived maximum intensity projection (MIP) images from each subject, and the areas with the most intense temperature and glucose uptake within the supraclavicular regions were compared. Relationships between supraclavicular temperatures (TSCR) from IRT and the metabolic rate of glucose uptake (MR(gluc)) from PET/CT were determined. Results: Glucose uptake on MR(gluc)MIP was found to correlate positively with a change in TSCR relative to a reference region (r2 = 0.721; P = 0.008). Spatial overlap between areas of maximal MR(gluc)MIP and maximal TSCR was 29.5% ± 5.1%. Prolonged cooling, for 60 min, was associated with a further TSCR rise, compared with cooling for 10 min. Conclusion: The supraclavicular hotspot identified on IRT closely corresponded to the area of maximal uptake on PET/CT-derived MR(gluc)MIP images. Greater increases in relative TSCR were associated with raised glucose uptake. IRT should now be considered a suitable method for measuring BAT activation, especially in populations for whom PET/CT is not feasible, practical, or repeatable.
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影响因子：
2.5
作者：
Jang C;Jalapu S;Thuzar M;Law PW;Jeavons S;Barclay JL;Ho KK
通讯作者：
Ho KK
影响因子：
29
作者：
Ramage LE;Akyol M;Fletcher AM;Forsythe J;Nixon M;Carter RN;van Beek EJ;Morton NM;Walker BR;Stimson RH
通讯作者：
Stimson RH
影响因子：
7.1
作者：
Vosselman, Maarten J.;Brans, Boudewijn;Lichtenbelt, Wouter D. van Marken
通讯作者：
Lichtenbelt, Wouter D. van Marken
影响因子：
2.7
作者：
Robinson, Lindsay J.;Law, James M.;Budge, Helen
通讯作者：
Budge, Helen
影响因子：
158.5
作者：
Virtanen, Kirsi A.;Lidell, Martin E.;Nuutila, Pirjo
通讯作者：
Nuutila, Pirjo