A core-shell-shell nanoplatform upconverting near-infrared light at 808 nm for luminescence imaging and photodynamic therapy of cancer.
A core-shell-shell nanoplatform upconverting near-infrared light at 808 nm for luminescence imaging and photodynamic therapy of cancer.
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核-壳-壳纳米平台上转换 808 nm 近红外光，用于癌症的发光成像和光动力治疗
DOI：
10.1038/srep10785
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发表时间：
2015-06-02
影响因子：
4.6
通讯作者：
Zhu G
中科院分区：
文献类型：
--
作者：
Ai F;Ju Q;Zhang X;Chen X;Wang F;Zhu G
上转换纳米粒子（UCNPs）由于其典型的大反斯托克斯位移、深穿透生物组织、窄发射带和高时空分辨率而被广泛探索用于光动力学治疗（PDT）和成像。然而，传统的基于UCNP的PDT系统利用在980 nm处的激发，在该波长处水具有显著的吸收，从而导致细胞杀伤效应是由于过热效应而来自照射的巨大担忧。在这里，我们报告了一个有效的纳米平台，使用808 nm激发的NaYbF 4：Nd@NaGdF4：Yb/Er@NaGdF4核-壳-壳纳米粒子装载二氢卟酚e6和叶酸，同时成像和PDT。在此波长下，水的吸收最小化。实现高能量转移效率以产生细胞毒性单线态氧。我们的纳米平台以浓度、时间和受体依赖的方式有效地杀死癌细胞。更重要的是，我们的纳米平台仍然能够在15 mm厚度的肌肉组织下有效地产生单线态氧，但980 nm激发不能，这表明我们的系统实现了更高的穿透深度。这些结果意味着我们的纳米平台具有通过PDT有效杀死内源性肿瘤或大肿瘤中心的能力，这显著提高了使用基于UCNP的PDT系统的抗癌功效，并拓宽了可以治愈的肿瘤类型。
Upconversion nanoparticles (UCNPs) have been extensively explored for photodynamic therapy (PDT) and imaging due to their representative large anti-Stokes shifts, deep penetration into biological tissues, narrow emission bands and high spatial-temporal resolution. Conventional UCNP-based PDT system, however, utilizes exitation at 980 nm, at which water has significant absorption, leading to a huge concern that the cell killing effect is from the irradiation due to overheating effect. Here we report an efficient nanoplatform using 808-nm excited NaYbF4:Nd@NaGdF4:Yb/Er@NaGdF4core−shell−shell nanoparticles loaded with Chlorin e6 and folic acid for simultaneous imaging and PDT. At this wavelength, the absorption of water is minimized. High energy transfer efficiency is achieved to generate cytotoxic singlet oxygen. Our nanoplatform effectively kills cancer cells in concentration-, time- and receptor-dependent manners. More importantly, our nanoplatform is still able to efficiently generate singlet oxygen beneath 15-mm thickness of muscle tissue but 980 nm excitation cannot, showing that a higher penetration depth is achieved by our system. These results imply that our nanoplatform has the ability to effectively kill intrinsic tumor or the center of large tumors through PDT, which significantly improves the anticancer efficacy using UCNP-based PDT system and broadens the types of tumors that could be cured.
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上转换纳米颗粒：设计、纳米化学及其在治疗诊断学中的应用
影响因子：
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作者：
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DOI：
10.1073/pnas.1114551109
发表时间：
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影响因子：
11.1
作者：
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通讯作者：
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