CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: the Framingham Heart Study.

CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: the Framingham Heart Study.
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DOI:
10.1002/jmri.24239
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发表时间:
2014-04
影响因子:
4.4
通讯作者:
Manning, Warren J.
Manning, Warren J.
中科院分区:
医学2区
文献类型:
--
作者:
Chuang, Michael L.;Gona, Philimon;Hautvast, Gilion L. T. F.;Salton, Carol J.;Breeuwer, Marcel;O'Donnell, Christopher J.;Manning, Warren J.

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采用计算机辅助分析确定健康成人左心室(LV)容积、质量和射血分数(EF)的性别特异性参考值,并检查年龄对LV参数的影响。我们检查了来自1494名Fractional Heart Study Offspring队列成员的数据,这些数据使用短轴叠加电影SSFP CMR获得,确定了健康参考组(无心血管疾病、高血压或LV室壁运动异常),并使用计算机辅助边界检测确定了LV体积和质量的性别特异性第95百分位数阈值上限和EF的第5百分位数阈值下限。在二次分析中,我们将参与者按年龄分层,并测试了各年龄组的线性趋势。参照组包括685名成人(423名女性; 61±9岁)。男性在不考虑常规体型测量值之前和之后的左心室体积和质量均大于男性(所有p<0.001)。女性的EF更高(73±6 vs. 71± 6%,p=0.0002)。在两种性别中,LV体积随着年龄的增长而下降,即使在未成年后也是如此。左心室质量指数不随年龄变化。在两种性别中,左心室射血分数和同心度随年龄增加而增加。我们提供了来自CMR的LV参考值。LV体积、EF和几何形状存在显着的年龄和性别差异,而质量在性别之间存在差异,但在年龄组之间没有差异。
To determine sex-specific reference values for left ventricular (LV) volumes, mass and ejection fraction (EF) in healthy adults using computer-aided analysis and to examine the effect of age on LV parameters. We examined data from 1494 members of the Framingham Heart Study Offspring cohort, obtained using short-axis stack cine SSFP CMR, identified a healthy reference group (without cardiovascular disease, hypertension, or LV wall motion abnormality) and determined sex-specific upper 95th percentile thresholds for LV volumes and mass, and lower 5th percentile thresholds for EF using computer-assisted border detection. In secondary analyses we stratified participants by age-decade and tested for linear trend across age groups. The reference group comprised 685 adults (423F; 61±9 years). Men had greater LV volumes and mass, before and after indexation to common measures of body size (all p<0.001). Women had greater EF (73±6 vs. 71±6%, p=0.0002). LV volumes decreased with greater age in both sexes, even after indexation. Indexed LV mass did not vary with age. LV EF and concentricity increased with greater age in both sexes. We present CMR-derived LV reference values. There are significant age and sex differences in LV volumes, EF and geometry, while mass differs between sexes but not age groups.
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