Mapping Second Chromosome Mutations to Defined Genomic Regions in Drosophila melanogaster.

Mapping Second Chromosome Mutations to Defined Genomic Regions in Drosophila melanogaster.
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DOI:
10.1534/g3.117.300289
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发表时间:
2018-01-04
期刊:
G3 (Bethesda, Md.)
影响因子:
--
通讯作者:
Cook KR
Cook KR
中科院分区:
其他
文献类型:
--
作者:
Kahsai L;Cook KR

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布卢明顿果蝇库存中心目前保存着数百种与序列定义基因无关的突变的黑腹果蝇。它们被保存下来是因为它们具有有趣的功能丧失表型。通过将这些突变与特定的基因组间隔联系起来,这些突变的实验价值将会增加,这样遗传学家就可以更容易地将它们与注释基因联系起来。在这里,我们报告了在Bloomington收集的85个第二染色体互补组的定位,以特定的,小簇的连续基因或测序基因组中的单个基因。这些信息对于那些对特定表型相关过程感兴趣的果蝇遗传学家和那些寻找影响特定序列定义基因的突变的人来说是有价值的。
Hundreds of Drosophila melanogaster stocks are currently maintained at the Bloomington Drosophila Stock Center with mutations that have not been associated with sequence-defined genes. They have been preserved because they have interesting loss-of-function phenotypes. The experimental value of these mutations would be increased by tying them to specific genomic intervals so that geneticists can more easily associate them with annotated genes. Here, we report the mapping of 85 second chromosome complementation groups in the Bloomington collection to specific, small clusters of contiguous genes or individual genes in the sequenced genome. This information should prove valuable to Drosophila geneticists interested in processes associated with particular phenotypes and those searching for mutations affecting specific sequence-defined genes.
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