Estimation of Serial Interval and Reproduction Number to Quantify the Transmissibility of SARS-CoV-2 Omicron Variant in South Korea.

Estimation of Serial Interval and Reproduction Number to Quantify the Transmissibility of SARS-CoV-2 Omicron Variant in South Korea.
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DOI:
10.3390/v14030533
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发表时间:
2022-03-04
期刊:
Viruses
影响因子:
--
通讯作者:
Ryu S
Ryu S
中科院分区:
其他
文献类型:
--
作者:
Kim D;Ali ST;Kim S;Jo J;Lim JS;Lee S;Ryu S

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自 2022 年 1 月下旬起,严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的 omicron 变种 (B.1.1.529) 是韩国的主要变种。在这项研究中,我们的目的是报告对序列间隔分布和繁殖数量的早期估计,以量化 2021 年 11 月 25 日至 2021 年 12 月 31 日期间 omicron 变种在韩国的传播能力。我们分析了 427 个本地 omicron 变种例并重建了 73 个传输对。我们使用最大似然估计来评估首次本地暴发中 74 例本地病例的传播对数据和繁殖数的序列区间分布。我们估计平均序列间隔为 3.78(标准差,0.76)天,儿童感染者(3.0 天)明显短于成人感染者(5.0 天)(p < 0.01)。我们估计,在第一次局部爆发期间,omicron 变种的平均繁殖数为 1.72(95% CrI,1.60-1.85)。应严格遵守公共卫生措施,特别是针对儿童,以降低高度传播的 omicron 变种在社区中的传播风险。
The omicron variant (B.1.1.529) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the predominant variant in South Korea from late January 2022. In this study, we aimed to report the early estimates of the serial interval distribution and reproduction number to quantify the transmissibility of the omicron variant in South Korea between 25 November 2021 and 31 December 2021. We analyzed 427 local omicron cases and reconstructed 73 transmission pairs. We used a maximum likelihood estimation to assess serial interval distribution from transmission pair data and reproduction numbers from 74 local cases in the first local outbreak. We estimated that the mean serial interval was 3.78 (standard deviation, 0.76) days, which was significantly shorter in child infectors (3.0 days) compared to adult infectors (5.0 days) (p < 0.01). We estimated the mean reproduction number was 1.72 (95% CrI, 1.60–1.85) for the omicron variant during the first local outbreak. Strict adherence to public health measures, particularly in children, should be in place to reduce the transmission risk of the highly transmissible omicron variant in the community.
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