Vibrissa motor cortex activity suppresses contralateral whisking behavior.

Vibrissa motor cortex activity suppresses contralateral whisking behavior.
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Vibrissa运动皮层活性抑制对侧搅拌行为。

DOI:
10.1038/nn.4437
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发表时间:
2017-01
影响因子:
25
通讯作者:
Brecht M
Brecht M
中科院分区:
医学1区
文献类型:
--
作者:
Ebbesen CL;Doron G;Lenschow C;Brecht M

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解剖,刺激和病变的数据牵连触须运动皮层在胡须电机控制。对运动皮层的研究集中在运动的产生上,但是触须运动皮层的活动和搅拌之间的相关性很弱。触须运动皮层的确切作用仍然未知。我们记录了触须运动皮层神经元在各种形式的触须触摸,这总是与胡须的延长和运动。自由搅拌、触诊物体和社会接触都会导致大脑皮层活动减少。为了理解这种活性降低,我们进行了细胞内记录、纳米刺激和体内全细胞记录。社会面部触摸导致减少尖峰活动,降低细胞兴奋性和膜超极化。通过皮层内微刺激激活触须运动皮层引起触须收缩,好像中止触须触摸。各种触须运动皮层失活协议导致对侧延长和胡须运动增加。这些数据共同指向运动抑制作为触须运动皮层活动的主要功能。
Anatomical, stimulation and lesion data implicate vibrissa motor cortex in whisker motor control. Work on motor cortex focused on movement generation, but correlations between vibrissa motor cortex activity and whisking are weak. The exact role of vibrissa motor cortex remains unknown. We recorded vibrissa motor cortex neurons during various forms of vibrissal touch, which were invariably associated with whisker protraction and movement. Free whisking, object palpation and social touch all resulted in decreased cortical activity. To understand this activity decrease, we performed juxtacellular recordings, nanostimulation and in vivo whole-cell-recordings. Social facial touch resulted in decreased spiking activity, decreased cell excitability and membrane hyperpolarization. Activation of vibrissa motor cortex by intra-cortical microstimulation elicited whisker retraction, as if to abort vibrissal touch. Various vibrissa motor cortex inactivation protocols resulted in contralateral protraction and increased whisker movements. These data collectively point to movement suppression as a prime function of vibrissa motor cortex activity.
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