Adaptive vaccination strategies to mitigate pandemic influenza: Mexico as a case study.
Adaptive vaccination strategies to mitigate pandemic influenza: Mexico as a case study.
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DOI：
10.1371/journal.pone.0008164
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发表时间：
2009-12-03
期刊：
影响因子：
3.7
通讯作者：
Miller MA
中科院分区：
文献类型：
--
作者：
Chowell G;Viboud C;Wang X;Bertozzi SM;Miller MA
我们利用年龄结构传播模型，根据2009年春季甲型H1N1流感大流行的当地流行病学数据进行校准，探讨了墨西哥针对大流行性流感的疫苗接种策略。在疫苗供应有限的情况下，我们评估了以年龄为目标的分配策略，这些策略要么优先考虑最年幼的儿童和65岁以上的人，就像季节性流感一样，要么根据大流行早期实时监测的住院和死亡的年龄模式，适应性地优先考虑年龄组。总体而言，适应性疫苗接种策略在广泛的疾病和疫苗覆盖参数方面优于季节性流感疫苗接种分配策略。这种建模方法可以为墨西哥和其他具有类似人口特征和疫苗资源问题的国家在减轻S-OIV大流行方面的政策提供信息。我们还讨论了在过去和未来流感大流行背景下与实施适应性疫苗接种战略相关的后勤问题。
We explore vaccination strategies against pandemic influenza in Mexico using an age-structured transmission model calibrated against local epidemiological data from the Spring 2009 A(H1N1) pandemic. In the context of limited vaccine supplies, we evaluate age-targeted allocation strategies that either prioritize youngest children and persons over 65 years of age, as for seasonal influenza, or adaptively prioritize age groups based on the age patterns of hospitalization and death monitored in real-time during the early stages of the pandemic. Overall the adaptive vaccination strategy outperformed the seasonal influenza vaccination allocation strategy for a wide range of disease and vaccine coverage parameters. This modeling approach could inform policies for Mexico and other countries with similar demographic features and vaccine resources issues, with regard to the mitigation of the S-OIV pandemic. We also discuss logistical issues associated with the implementation of adaptive vaccination strategies in the context of past and future influenza pandemics.
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作者：
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