CpG-Oligodeoxynucleotides Improved Irradiation-Induced Injuries by G-CSF and IL-6 Up-Regulation
CpG-Oligodeoxynucleotides Improved Irradiation-Induced Injuries by G-CSF and IL-6 Up-Regulation
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CpG-寡脱氧核苷酸通过上调 G-CSF 和 IL-6 改善辐射引起的损伤
DOI：
10.1159/000486153
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发表时间：
2017-12
影响因子：
--
通讯作者：
Jianming Cai
中科院分区：
文献类型：
--
作者：
Pei Zhang;Suhe Dong;Jiaming Guo;Yanyong Yang;Cong Liu;Bailong Li;Fu Gao;Xuejun Su;Jianming Cai
背景/目标：本研究探讨了三种CpG-ODNs的辐射防护作用及其机制。方法：小鼠经不同剂量（7 Gy或9 Gy）照射后，腹腔注射ODNs（50μg）或不注射ODNs（50μg）。进行测定以确定存活率和外周血中白色血细胞的数量。采用酶联免疫吸附法（ELISA）检测血清粒细胞集落刺激因子（G-CSF）、白细胞介素6（IL-6）和α干扰素（IFN-α）水平。结果：经ODNs预处理后，7 Gy照射小鼠的存活率由50%提高到100%左右。ODNs的施用增加了照射小鼠的WBC的数量。G-CSF、IL-6和IFN-α水平在ODNs处理后均显著上调。结论：三种ODNs均能保护小鼠免受辐射损伤。B-class ODNs通过上调G-CSF和IL-6的表达而具有最强的辐射防护作用。
Background/Aims: This study investigated the radioprotective properties of three classes of CpG-oligodeoxynucleotides (CpG-ODNs) and the underlying mechanisms. Methods: Mice irradiated at different doses(7Gy or 9Gy) were treated with or without ODNs(50μg via intraperitoneal injection). Assays were performed to determine survival rate and the number of white blood cell in peripheral blood. The levels of granulocyte-colony stimulating factor(G-CSF), interleukin 6(IL-6) and interferon-α (IFN-α) were measured using enzyme-linked immunosorbent assay (ELISA). Results: Survival rate of mice irradiated in 7Gy was increased from 50% to about 100% with ODNs pretreatment. ODNs administration increased the number of WBCs of irradiated mice. G-CSF, IL-6 and IFN-α levels were up-regulated with ODNs treatment. Conclusion: All three classes of ODNs protected mice from irradiation-induced injuries. B-class ODNs exhibited the most potent radioprotective property via the up-regulation of G-CSF and IL-6.
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影响因子：
9
作者：
通讯作者：
--
CpG-寡脱氧核苷酸治疗可预防电离辐射引起的肠道损伤
影响因子：
3.7
作者：
Zhang C;Ni J;Li BL;Gao F;Liu H;Liu W;Huang YJ;Cai JM
通讯作者：
Cai JM
影响因子：
5.4
作者：
A. Krug;S. Rothenfusser;V. Hornung;B. Jahrsdörfer;S. Blackwell;Z. Ballas;S. Endres;A. Krieg;G. Hartmann
通讯作者：
A. Krug;S. Rothenfusser;V. Hornung;B. Jahrsdörfer;S. Blackwell;Z. Ballas;S. Endres;A. Krieg;G. Hartmann
全身照射后给予小鼠 CpG 寡脱氧核苷酸对骨髓造血的辐射保护
影响因子：
2
作者：
Zhang, Chao;Lin, Jing;Cai, Jianming
通讯作者：
Cai, Jianming
DOI：
10.1073/pnas.84.24.9035
发表时间：
1987-12-01
影响因子：
11.1
作者：
IKEBUCHI, K;WONG, GG;OGAWA, M
通讯作者：
OGAWA, M