Mood-related central and peripheral clocks.
Mood-related central and peripheral clocks.
复制标题
与情绪有关的中央和外围钟。
DOI：
10.1111/ejn.14253
复制
发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
McClung CA
中科院分区：
文献类型：
--
作者：
Ketchesin KD;Becker-Krail D;McClung CA
心境障碍，包括重性抑郁症、双相情感障碍和季节性情感障碍，是影响全球人口很大一部分的衰弱性疾病。患有情绪障碍的个体通常表现出昼夜节律和睡眠的显著紊乱。此外，环境对昼夜节律的干扰可能会加速或加剧脆弱个体的情绪症状。生物钟存在于整个中枢神经系统和外周，在那里它们调节与情绪调节有关的各种生理过程。这些过程包括单胺能和多巴胺能传递、下丘脑-垂体-肾上腺轴功能、代谢和免疫功能。虽然昼夜节律紊乱和情绪调节之间似乎有明确的联系，但这种联系的机制仍不清楚。这篇综述将涉及昼夜节律系统和这些过程之间的相互作用，并讨论它们在情绪障碍发展中的潜在作用。虽然临床研究，大部分的审查将集中在动物模型的研究，这是试图阐明昼夜节律基因调节情绪的分子和细胞机制。
Mood disorders, including major depression, bipolar disorder, and seasonal affective disorder, are debilitating disorders that affect a significant portion of the global population. Individuals suffering from mood disorders often show significant disturbances in circadian rhythms and sleep. Moreover, environmental disruptions to circadian rhythms can precipitate or exacerbate mood symptoms in vulnerable individuals. Circadian clocks exist throughout the central nervous system and periphery, where they regulate a wide variety of physiological processes implicated in mood regulation. These processes include monoaminergic and glutamatergic transmission, hypothalamic-pituitary-adrenal axis function, metabolism, and immune function. While there seems to be a clear link between circadian rhythm disruption and mood regulation, the mechanisms that underlie this association remain unclear. This review will touch on the interactions between the circadian system and each of these processes and discuss their potential role in the development of mood disorders. While clinical studies are presented, much of the review will focus on studies in animal models, which are attempting to elucidate the molecular and cellular mechanisms in which circadian genes regulate mood.
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影响因子：
3.7
作者：
Bellet MM;Vawter MP;Bunney BG;Bunney WE;Sassone-Corsi P
通讯作者：
Sassone-Corsi P
影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
DOI：
10.1073/pnas.1014523107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Andrews, Jessica L.;Zhang, Xiping;Esser, Karyn A.
通讯作者：
Esser, Karyn A.
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U
DOI：
10.4049/jimmunol.1001026
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castanon-Cervantes O;Wu M;Ehlen JC;Paul K;Gamble KL;Johnson RL;Besing RC;Menaker M;Gewirtz AT;Davidson AJ
通讯作者：
Davidson AJ