Serum interleukin-6 in patients with burning mouth syndrome and relationship with depression and perceived pain.
Serum interleukin-6 in patients with burning mouth syndrome and relationship with depression and perceived pain.
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DOI：
10.1155/2007/45327
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发表时间：
2007
影响因子：
4.6
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Chen Q;Xia J;Lin M;Zhou H;Li B
Objective.探讨灼口综合征（BMS）患者血清白细胞介素6（IL-6）的变化及其临床意义。 方法. 48名BMS患者和31名健康对照参与了这项研究。采用ELISA法测定血清白细胞介素-6（IL-6）水平。分别采用汉密尔顿抑郁量表（HRSD）和视觉模拟量表（VAS）量化受试者的抑郁状态和疼痛水平。 结果15例（31%）患者表现出明显的抑郁症状（HRSD ≥ 16）。患者的HRSD评分显著高于对照组，且与VAS值呈正相关（P = .002）。患者的血清白细胞介素-6远低于对照组，并与VAS值呈负相关（P = .011）。然而，没有发现白细胞介素-6和HRSD评分之间的显着关系（P = 0.317）。结论.灼口综合征患者血清白细胞介素-6水平降低，与慢性疼痛呈负相关。心理和神经疾病可能是BMS发病的促发因素。
Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitiate depressive status and pain levels of subjects, respectively. Results. 15 (31%) patients displayed substantial depressive symptoms (HRSD ≧ 16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P = .002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P = .011). However, no significant relations were found between interleukin-6 and HRSD scores (P = .317). Conclusions. Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.
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创伤后，通过上调白介素（IL）6和IL-6受体的表达来加速小鼠的神经再生。
影响因子：
15.3
作者：
Hirota, H;Kiyama, H;Kishimoto, T;Taga, T
通讯作者：
Taga, T
影响因子：
2.5
作者：
Geiss, A;Varadi, E;Anton, F
通讯作者：
Anton, F
DOI：
10.1016/j.tripleo.2004.01.021
发表时间：
2005-01-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Lamey, PJ;Freeman, R;Rees, T
通讯作者：
Rees, T
影响因子：
3.7
作者：
Maes, M;Libbrecht, I;Neels, H
通讯作者：
Neels, H
影响因子：
7.4
作者：
Lauria, G;Majorana, A;Sapelli, P
通讯作者：
Sapelli, P