Roles for nuclear organization in the maintenance of genome stability.
Roles for nuclear organization in the maintenance of genome stability.
复制标题
核组织在维持基因组稳定性中的作用。
作者：
S. Nagai;P. Heun;S. Gasser
最近的研究结果表明，染色质动力学和核组织不仅对于基因调控很重要，而且对于维持基因组稳定性也很重要。得益于允许活细胞中特定染色质域可视化的新技术，最近的研究表明双链断裂和修饰酶的空间动力学可以影响修复。通过证明核组织的扰动可导致基因扩增、缺失、易位和端到端端粒融合事件，证实了空间组织在 DNA 损伤修复中的重要性。
Recent findings demonstrate that chromatin dynamics and nuclear organization are not only important for gene regulation but also for the maintenance of genome stability. Thanks to novel techniques that allow the visualization of specific chromatin domains in living cells, recent studies have demonstrated that the spatial dynamics of double-strand breaks and modifying enzymes can influence repair. The importance of the spatial organization in the repair of DNA damage has been confirmed by demonstrating that perturbation of nuclear organization can lead to gene amplifications, deletions, translocations and end-to-end telomere fusion events.
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影响因子：
3.3
作者：
Lisa C. Kadyk;Leland H. Hartwell
通讯作者：
Lisa C. Kadyk;Leland H. Hartwell
影响因子：
16
作者：
Vogelauer, M;Rubbi, L;Grunstein, M
通讯作者：
Grunstein, M
影响因子：
16
作者：
Yusufzai, TM;Tagami, H;Felsenfeld, G
通讯作者：
Felsenfeld, G
影响因子：
64.5
作者：
Ashby J. Morrison;Jessica Highland;N. Krogan;Ayelet Arbel-Eden;J. Greenblatt;J. Haber;Xuetong Shen
通讯作者：
Ashby J. Morrison;Jessica Highland;N. Krogan;Ayelet Arbel-Eden;J. Greenblatt;J. Haber;Xuetong Shen
影响因子：
10.5
作者：
Kaeberlein, M;McVey, M;Guarente, L
通讯作者：
Guarente, L