Prognostic and Clinicopathological Value of Rac1 in Cancer Survival: Evidence from a Meta-Analysis.
Prognostic and Clinicopathological Value of Rac1 in Cancer Survival: Evidence from a Meta-Analysis.
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DOI：
10.7150/jca.24824
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发表时间：
2018
影响因子：
3.9
通讯作者：
Zhou M
中科院分区：
文献类型：
--
作者：
Lou S;Wang P;Yang J;Ma J;Liu C;Zhou M
目的：Rac 1在癌症生存中的作用已被广泛研究。然而，Rac 1的预后和临床病理价值仍然没有定论。我们进行了一项荟萃分析，以阐明Rac 1在癌症生存中的作用以及其与临床病理特征的关系。方法：从PubMed、科克伦图书馆、Embase和Web of Science数据库中检索符合条件的研究。合并的风险比（HR）和比值比（OR）以及相应的95%置信区间（CI）用于检测Rac 1的预后和临床病理学作用。结果：共纳入14篇文献，1793例患者。总生存期（OS）（HR=2.02，95% CI：1.70-2.39）和无病生存期（DFS）（HR=2.64，95% CI：1.71-4.09）的合并HR表明Rac 1具有显著的不良预后效应。Rac 1的阳性表达与肿瘤分期、血管浸润和淋巴结转移有关，但与组织分化程度无关。敏感性试验显示，没有一项研究显著改变OS或DFS。Egger检验和Begg漏斗图检验均未发现发表偏倚。结论：Rac 1基因可作为预测肿瘤预后的潜在指标。此外，Rac 1表达与恶性相关表型相关。
Purpose: The role of Rac1 in cancer survival has been widely studied. However, the prognostic and clinicopathological value of Rac1 remains inconclusive. We performed a meta-analysis to clarify the role of Rac1 in cancer survival as well as its association with clinicopathological features. Methods: Eligible studies were searched from PubMed, Cochrane Library, Embase, and Web of Science databases. The pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to detect the prognostic and clinicopathological role of Rac1. Results: A total of 14 studies including 1793 patients were enrolled in the present meta-analysis. Pooled HR for overall survival (OS) (HR=2.02, 95% CI: 1.70-2.39) and disease-free survival (DFS) (HR=2.64, 95% CI: 1.71-4.09) indicated a significant poor prognostic effect for Rac1. Positive Rac1 expression was found to be correlated with tumor stage, blood vessel invasion, and lymph metastasis, but not with histological differentiation. Sensitivity test showed no single study altered OS or DFS significantly. No publication bias was detected by Egger's test and Begg's funnel plot test. Conclusion: This meta-analysis indicated that Rac1 could be used as a potential marker to predict cancer prognosis. Additionally, Rac1 expression was associated with the malignancy-related phenotype.
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