The Prognostic Value of PLR in Lung Cancer, a Meta-analysis Based on Results from a Large Consecutive Cohort.
The Prognostic Value of PLR in Lung Cancer, a Meta-analysis Based on Results from a Large Consecutive Cohort.
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DOI：
10.1038/srep34823
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发表时间：
2016-10-05
影响因子：
4.6
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Ding N;Pang Z;Shen H;Ni Y;Du J;Liu Q
近年来，许多研究探讨了血小板与淋巴细胞比值（PLR）对肺癌患者预后的价值，但结果仍存在争议。我们收集我院2006 - 2011年间1388例接受手术的肺癌患者的术前、临床病理及随访资料，并查阅Embase、Pubmed、Web of science数据库的相关文章，进行meta分析，明确肺癌患者PLR与预后的关系。最后，纳入了我们研究的11篇文章，结果表明，PLR升高与总生存率呈负相关（HR = 1.33, 95% CI: 1.10-1.62），但与无进展生存率无关（HR = 1.21, 95% CI: 0.97-1.49）。亚组分析显示，高PLR与非小细胞肺癌的低生存率相关（HR = 1.43, 95% CI: 1.14-1.78），但与小细胞肺癌无关（HR = 1.10, 95% CI: 0.76-1.58）。此外，对于化疗或放疗患者（HR = 1.66, 95% CI: 1.15 ~ 2.38）和晚期患者（HR = 1.41, 95% CI: 1.19 ~ 1.68）， PLR具有显著的预后价值。此外，当PLR截断值在150 ~ 200之间时，结果具有显著性（HR = 1.47, 95% CI: 1.18 ~ 1.82）。总之，本荟萃分析显示，PLR升高与肺癌预后不良相关。
Recently, many studies have been conducted to explore prognostic value of platelet to lymphocyte ratio (PLR) for patients with lung cancer, while the results remain controversial. We collected pretreatment, clinicopathological and follow-up data of 1388 lung cancer patients receiving surgery between 2006 and 2011 in our hospital, and reviewed relevant articles from Embase, Pubmed, Web of science databases, then performed a meta-analysis to clarify the relationship between PLR and prognosis of lung cancer patients. Finally, 11 articles with our study were included, results indicated elevated PLR was negatively related to overall survival (HR = 1.33, 95% CI: 1.10–1.62), but not related to progress-free survival (HR = 1.21, 95% CI: 0.97–1.49). Subgroup analysis suggested high PLR was correlated with poor survival in non-small cell lung cancer (HR = 1.43, 95% CI: 1.14–1.78), but not in small cell lung cancer (HR = 1.10, 95% CI: 0.76–1.58). Besides, for patients treated by chemotherapy or radiotherapy (HR = 1.66, 95% CI: 1.15–2.38) and patients in late stage (HR = 1.41, 95% CI: 1.19–1.68), PLR had significantly prognostic value. Additionally, the result was significant for patients when cut-off value of PLR was between 150 and 200 (HR = 1.47, 95% CI: 1.18–1.82). In Conclusion, this meta-analysis revealed that elevated PLR was associated with poor prognosis in lung cancer.
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