Cavitation Characterization of Size-Isolated Microbubbles in a Vessel Phantom Using Focused Ultrasound.
Cavitation Characterization of Size-Isolated Microbubbles in a Vessel Phantom Using Focused Ultrasound.
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使用聚焦超声对血管体模中尺寸隔离的微泡进行空化表征。
DOI：
10.3390/pharmaceutics14091925
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发表时间：
2022-09-12
期刊：
影响因子：
5.4
通讯作者：
Borden, Mark
中科院分区：
文献类型：
--
作者：
Martinez, Payton;Bottenus, Nick;Borden, Mark
关键词：
Pharmaceutical delivery can be noninvasively targeted on-demand by microbubble (MB) assisted focused ultrasound (FUS). Passive cavitation detection (PCD) has become a useful method to obtain real-time feedback on MB activity due to a FUS pulse. Previous work has demonstrated the acoustic PCD response of MBs at a variety of acoustic parameters, but few have explored variations in microbubble parameters. The goal of this study was to determine the acoustic response of different MB size populations and concentrations. Four MB size distributions were prepared (2, 3, 5 µm diameter and polydisperse) and pulled through a 2% agar wall-less vessel phantom. FUS was applied by a 1.515 MHz geometrically focused transducer for 1 ms pulses at 1 Hz PRF and seven distinct mechanical indices (MI) ranging from 0.01 to 1.0 (0.0123 to 1.23 MPa PNP). We found that the onset of harmonic (HCD) and broadband cavitation dose (BCD) depends on the mechanical index, MB size and MB concentration. When matched for MI, the HCD and BCD rise, plateau, and decline as microbubble concentration is increased. Importantly, when microbubble size and concentration are combined into gas volume fraction, all four microbubble size distributions align to similar onset and peak; these results may help guide the planning and control of MB + FUS therapeutic procedures.
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影响因子：
3.5
作者：
Chomas, JE;Dayton, P;Ferrara, K
通讯作者：
Ferrara, K
影响因子：
4.6
作者：
Chu PC;Chai WY;Tsai CH;Kang ST;Yeh CK;Liu HL
通讯作者：
Liu HL
DOI：
10.1109/tbme.2009.2034533
发表时间：
2010-01
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Choi JJ;Feshitan JA;Baseri B;Wang S;Tung YS;Borden MA;Konofagou EE
通讯作者：
Konofagou EE
影响因子：
2.3
作者：
Hyvelin, Jean-Marc;Gaud, Emmanuel;Frinking, Peter
通讯作者：
Frinking, Peter
影响因子：
2.4
作者：
Acconcia, Christopher N.;Wright, Alex;Goertz, David E.
通讯作者：
Goertz, David E.