Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging.
Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging.
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DOI：
10.1038/srep33264
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发表时间：
2016-09-15
影响因子：
4.6
通讯作者：
Liu HL
中科院分区：
文献类型：
--
作者：
Chu PC;Chai WY;Tsai CH;Kang ST;Yeh CK;Liu HL
微泡聚焦超声(FUS)可以暂时打开血脑屏障(BBB)，而微泡的空化活动在BBB开放过程中起着关键作用。以往的研究使用对比增强磁共振成像(CE-MRI)来将机械指数(MI)与BBB开放程度相关联，但MI仅能部分测量声学活动，并且CE-MRI不能完全探索药效学/药代动力学行为之间的相关性。最近，空化指数(CI)被用来作为微泡-超声稳定空化的指标，也可以作为衡量FUS诱导的血脑屏障开放程度的有效指标。本研究通过动态对比增强(DCE)-MRI分析和被动空化检测(PCD)分析，探讨通过MI和CI这两个指标来测量FUS诱导的BBB开放水平的可行性。DCE-MRI的药效学/药代动力学参数用于确定FUS诱导的血脑屏障开放程度。我们的结果表明，DCE-MRI可以成功地评价BBB开放的药效学/药动学行为，并且与MI和CI高度相关，这意味着使用这两个指标来衡量FUS诱导的BBB开放的规模是可行的。这一发现可能有助于将聚焦超声作为一种安全可靠的非侵入性中枢神经系统药物输送的设计。
Focused ultrasound (FUS) with microbubbles can temporally open the blood-brain barrier (BBB), and the cavitation activities of microbubbles play a key role in the BBB-opening process. Previous attempts used contrast-enhanced magnetic resonance imaging (CE-MRI) to correlate the mechanical index (MI) with the scale of BBB-opening, but MI only partially gauged acoustic activities, and CE-MRI did not fully explore correlations of pharmacodynamic/pharmacokinetic behaviors. Recently, the cavitation index (CI) has been derived to serve as an indicator of microbubble-ultrasound stable cavitation, and may also serve as a valid indicator to gauge the level of FUS-induced BBB opening. This study investigates the feasibility of gauging FUS-induced BBB opened level via the two indexes, MI and CI, through dynamic contrast-enhanced (DCE)-MRI analysis as well as passive cavitation detection (PCD) analysis. Pharmacodynamic/pharmacokinetic parameters derived from DCE-MRI were characterized to identify the scale of FUS-induced BBB opening. Our results demonstrated that DCE-MRI can successfully access pharmacodynamic/pharmacokinetic BBB-opened behavior, and was highly correlated both with MI and CI, implying the feasibility in using these two indices to gauge the scale of FUS-induced BBB opening. The proposed finding may facilitate the design toward using focused ultrasound as a safe and reliable noninvasive CNS drug delivery.
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影响因子：
19.7
作者：
Hynynen, K;McDannold, N;Jolesz, FA
通讯作者：
Jolesz, FA
DOI：
10.1109/tbme.2009.2034533
发表时间：
2010-01
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Choi JJ;Feshitan JA;Baseri B;Wang S;Tung YS;Borden MA;Konofagou EE
通讯作者：
Konofagou EE
影响因子：
2.9
作者：
Liu, Hao-Li;Wai, Yau-Yau;Wang, Jiun-Jie
通讯作者：
Wang, Jiun-Jie
影响因子：
3.5
作者：
McDannold, N;Vykhodtseva, N;Hynynen, K
通讯作者：
Hynynen, K
影响因子：
2.9
作者：
Duck, FA
通讯作者：
Duck, FA