The aging gut microbiome and its impact on host immunity.
The aging gut microbiome and its impact on host immunity.
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DOI：
10.1038/s41435-021-00126-8
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发表时间：
2021-10
影响因子：
5
通讯作者：
Noti M
中科院分区：
文献类型：
--
作者：
Bosco N;Noti M
微生物组在从出生到老年的宿主免疫系统的成熟、功能和调节中起着重要作用。作为回报，免疫系统与居住在我们体内的数万亿有益微生物共同进化出一种互惠互利的关系，同时建立有效的反应来对抗入侵的病原体。随着年龄的增长，免疫系统和肠道微生物组的组成和功能都发生了显著变化，这与对传染病的易感性增加和疫苗接种反应降低有关。新的研究表明，针对年龄相关的生态失调可以改善健康和寿命，部分原因是通过减少系统性低度炎症和免疫衰老-衰老过程的两个标志。然而，年龄相关的生态失调和相关的免疫细胞功能下降的因果关系尚未在临床环境中得到证实。本综述旨在（i）概述衰老免疫系统和肠道微生物组的标志，（ii）讨论肠道微生物群落结构中与年龄相关的变化（作为微生物老化引入）对宿主免疫适应性和健康的影响，以及（iii）总结益生元和益生菌临床干预试验，旨在通过微生物组调节或复兴来加强免疫细胞功能与年龄相关的下降。
The microbiome plays a fundamental role in the maturation, function, and regulation of the host-immune system from birth to old age. In return, the immune system has co-evolved a mutualistic relationship with trillions of beneficial microbes residing our bodies while mounting efficient responses to fight invading pathogens. As we age, both the immune system and the gut microbiome undergo significant changes in composition and function that correlate with increased susceptibility to infectious diseases and reduced vaccination responses. Emerging studies suggest that targeting age-related dysbiosis can improve health- and lifespan, in part through reducing systemic low-grade inflammation and immunosenescence—two hallmarks of the aging process. However—a cause and effect relationship of age-related dysbiosis and associated functional declines in immune cell functioning have yet to be demonstrated in clinical settings. This review aims to (i) give an overview on hallmarks of the aging immune system and gut microbiome, (ii) discuss the impact of age-related changes in the gut commensal community structure (introduced as microb-aging) on host-immune fitness and health, and (iii) summarize prebiotic- and probiotic clinical intervention trials aiming to reinforce age-related declines in immune cell functioning through microbiome modulation or rejuvenation.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
5.5
作者：
Bartholomeus, Esther;De Neuter, Nicolas;Mortier, Geert
通讯作者：
Mortier, Geert
影响因子：
5.9
作者：
Badal VD;Vaccariello ED;Murray ER;Yu KE;Knight R;Jeste DV;Nguyen TT
通讯作者：
Nguyen TT
影响因子：
82.9
作者：
Barcena, Clea;Valdes-Mas, Rafael;Lopez-Otin, Carlos
通讯作者：
Lopez-Otin, Carlos
影响因子：
6
作者：
Arai, S
通讯作者：
Arai, S