The Gut Microbiome, Aging, and Longevity: A Systematic Review.
The Gut Microbiome, Aging, and Longevity: A Systematic Review.
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DOI：
10.3390/nu12123759
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发表时间：
2020-12-07
期刊：
影响因子：
5.9
通讯作者：
Nguyen TT
中科院分区：
文献类型：
--
作者：
Badal VD;Vaccariello ED;Murray ER;Yu KE;Knight R;Jeste DV;Nguyen TT
衰老是由遗传和环境因素之间复杂的相互作用决定的。越来越多的证据表明，肠道微生物组是许多年龄相关变化的核心，包括免疫系统失调和对疾病的易感性。肠道微生物群在整个生命周期中经历了广泛的变化，与年龄相关的过程可能会影响肠道微生物群及其相关的代谢变化。这项系统性综述的目的是总结目前关于肠道微生物群多样性、组成和功能特征的衰老相关变化的文献。我们确定了27项适合纳入的正常和成功衰老的经验性人类研究。与年轻人相比，老年人，特别是年龄最大的老年人的微生物分类群，功能途径和代谢产物的α多样性更高。β多样性距离在各个发育阶段显着不同，甚至在最年长的成年人和最年轻的成年人之间也存在差异。分类组成和功能潜力的差异在不同的研究中有所不同，但阿克曼菌最一致的报道是随着年龄的增长而相对更丰富，而粪杆菌，拟杆菌科和毛螺菌科相对减少。老年人减少了与碳水化合物代谢和氨基酸合成相关的途径;然而，年龄最大的老年人表现出功能差异，将他们的微生物群与非老年人的微生物群区分开来，例如更大的短链脂肪酸生产潜力和增加的丁酸衍生物。虽然明确的解释是有限的横截面设计发表的报告，我们整合了微生物组成和下游功能途径和代谢产物的研究结果，提供可能的解释与年龄相关的过程。
Aging is determined by complex interactions among genetic and environmental factors. Increasing evidence suggests that the gut microbiome lies at the core of many age-associated changes, including immune system dysregulation and susceptibility to diseases. The gut microbiota undergoes extensive changes across the lifespan, and age-related processes may influence the gut microbiota and its related metabolic alterations. The aim of this systematic review was to summarize the current literature on aging-associated alterations in diversity, composition, and functional features of the gut microbiota. We identified 27 empirical human studies of normal and successful aging suitable for inclusion. Alpha diversity of microbial taxa, functional pathways, and metabolites was higher in older adults, particularly among the oldest-old adults, compared to younger individuals. Beta diversity distances significantly differed across various developmental stages and were different even between oldest-old and younger-old adults. Differences in taxonomic composition and functional potential varied across studies, but Akkermansia was most consistently reported to be relatively more abundant with aging, whereas Faecalibacterium, Bacteroidaceae, and Lachnospiraceae were relatively reduced. Older adults have reduced pathways related to carbohydrate metabolism and amino acid synthesis; however, oldest-old adults exhibited functional differences that distinguished their microbiota from that of young-old adults, such as greater potential for short-chain fatty acid production and increased butyrate derivatives. Although a definitive interpretation is limited by the cross-sectional design of published reports, we integrated findings of microbial composition and downstream functional pathways and metabolites, offering possible explanations regarding age-related processes.
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影响因子：
--
作者：
Biagi, Elena;Candela, Marco;Fairweather-Tait, Susan;Franceschi, Claudio;Brigidi, Patrizia
通讯作者：
Brigidi, Patrizia
影响因子：
5.2
作者：
Garcia-Mantrana I;Selma-Royo M;Alcantara C;Collado MC
通讯作者：
Collado MC
影响因子：
2.9
作者：
Drago, Lorenzo;Toscano, Marco;Mogna, Giovanni
通讯作者：
Mogna, Giovanni
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.
DOI：
10.1097/01.jgp.0000192501.03069.bc
发表时间：
2006-01-01
影响因子：
7.2
作者：
Depp, CA;Jeste, DV
通讯作者：
Jeste, DV