Spatial correlations of trabecular bone microdamage with local stresses and strains using rigid image registration.
Spatial correlations of trabecular bone microdamage with local stresses and strains using rigid image registration.
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使用刚性图像配准研究骨小梁微损伤与局部应力和应变的空间相关性。
DOI：
10.1115/1.4004164
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Guldberg,RobertE
中科院分区：
文献类型：
--
作者：
Nagaraja,Srinidhi;Skrinjar,Oskar;Guldberg,RobertE
虽然已知在超负荷和老化的情况下，骨小梁中会积累微损伤，但与局部骨衰竭相关的组织水平的应力和应变还不是很清楚。微损伤与微结构应力和应变的局部相关性要求采用基于微计算机断层扫描(Micro-CT)的有限元模型来精确配准组织切片。此外，选择用于分析的相关分辨率(即网格大小)可能会影响观测结果。因此，开发了一种自动、可重复和准确的图像配准算法来确定与微损伤启动相关的局部应力和应变的范围。使用二维刚性配准算法，将来自组织学和Micro-CT成像的骨结构对齐。一旦对齐，微损伤区域与基于Micro-CT的有限元分析获得的局部应力和应变在空间上相关。使用这种更复杂的配准技术，我们能够分析不同的空间网格分辨率对引发微损伤的局部应力和应变的影响。结果表明，与人工选择单个受损和未受损的小梁相比，对单个像素水平的网格细化(逐个像素的方法)更精确地定义了微损伤起始的范围。使用逐个像素的方法，我们证实了年轻奶牛的小梁骨在微损伤开始之前与年长的骨骼相比，保持了更高的局部应变。
Although microdamage is known to accumulate in trabecular bone with overloading and aging, the tissue-level stresses and strains associated with local bone failure are not well known. Local correlation of microdamage with microstructural stresses and strains requires methods to accurately register histological sections with micro-computed tomography (micro-CT) based finite element models. In addition, the resolution of correlation (i.e., grid size) selected for analysis may affect the observed results. Therefore, an automated, repeatable, and accurate image registration algorithm was developed to determine the range of local stresses and strains associated with microdamage initiation. Using a two-dimensional rigid registration algorithm, bone structures from histology and micro-CT imaging were aligned. Once aligned, microdamaged regions were spatially correlated with local stresses and strains obtained from micro-CT based finite element analysis. Using this more sophisticated registration technique, we were able to analyze the effects of varying spatial grid resolution on local stresses and strains initiating microdamage. The results indicated that grid refinement to the individual pixel level (pixel-by-pixel method) more precisely defined the range of microdamage initiation compared to manually selected individual damaged and undamaged trabeculae. Using the pixel-by-pixel method, we confirmed that trabecular bone from younger cows sustained higher local strains prior to microdamage initiation compared to older bone.
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DOI：
--
发表时间：
2009
期刊：
影响因子：
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