Maternal immunization with adjuvanted RSV prefusion F protein effectively protects offspring from RSV challenge and alters innate and T cell immunity.
Maternal immunization with adjuvanted RSV prefusion F protein effectively protects offspring from RSV challenge and alters innate and T cell immunity.
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DOI：
10.1016/j.vaccine.2020.10.065
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发表时间：
2020-11-25
期刊：
影响因子：
5.5
通讯作者：
Empey KM
中科院分区：
文献类型：
--
作者：
Eichinger KM;Kosanovich JL;Lipp MA;Perkins TN;Petrovsky N;Marshall C;Yondola MA;Empey KM
呼吸道合胞病毒（RSV）通常在婴儿中引起严重的呼吸道感染，在2-6个月之间达到高峰；直接接种疫苗不太可能有效的年龄。产妇免疫可以向新生儿提供高水平的抗体，提供即时保护。自然感染后，针对RSV F蛋白预融合构象（PreF）的抗体具有最大的中和能力，因此，当通过母亲接种疫苗获得时，可能为婴儿提供高度的RSV保护。然而，抗前f母体抗体对RSV暴露后婴儿免疫的影响尚未阐明。为了解决这一知识差距，接种了RSV PreF疫苗制剂的母鼠所生的后代感染了RSV，并随着时间的推移分析了它们的免疫反应。这些研究证明了rsv感染的母体免疫后代的安全性和有效性，但母体抗体水平高和下降与先天免疫和T细胞免疫的差异有关。
Respiratory syncytial virus (RSV) commonly causes severe respiratory tract infections in infants, peaking between 2–6 months of age; an age at which direct vaccination is unlikely to be effective. Maternal immunization can deliver high levels of antibodies to newborns, providing immediate protection. Following natural infection, antibodies targeting the prefusion conformation of RSV F protein (PreF) have the greatest neutralizing capacity and thus, may provide infants with a high degree of RSV protection when acquired through maternal vaccination. However, the influence of anti-PreF maternal antibodies on infant immunity following RSV exposure has not been elucidated. To address this knowledge gap, offspring born to dams immunized with a RSV PreF vaccine formulation were challenged with RSV and their immune responses were analyzed over time. These studies demonstrated safety and efficacy for RSV-challenged, maternally-immunized offspring but high and waning maternal antibody levels were associated with differential innate and T cell immunity.
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DOI：
10.1084/jem.20051166
发表时间：
2005-12-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.4
作者：
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通讯作者：
Peeples, Mark E.
影响因子：
7.3
作者：
Eichinger, Katherine M.;Kosanovich, Jessica L.;Empey, Kerry M.
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Empey, Kerry M.
影响因子：
3.7
作者：
Empey, Kerry M.;Orend, Jacob G.;Kolls, Jay K.
通讯作者：
Kolls, Jay K.
影响因子：
3.7
作者：
Ochola R;Sande C;Fegan G;Scott PD;Medley GF;Cane PA;Nokes DJ
通讯作者：
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