The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya.
The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya.
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DOI：
10.1371/journal.pone.0008088
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发表时间：
2009-12-02
期刊：
影响因子：
3.7
通讯作者：
Nokes DJ
中科院分区：
文献类型：
--
作者：
Ochola R;Sande C;Fegan G;Scott PD;Medley GF;Cane PA;Nokes DJ
呼吸道合胞病毒（RSV）是婴幼儿下呼吸道感染的主要病原。RSV特异性母体抗体（RSV-matAb）的衰减率，影响脐带血水平的因素，以及这些水平与感染保护之间的关系尚不清楚。出生队列（n = 635）在肯尼亚农村，进行了深入研究，以监测感染和描述与年龄相关的血清学特征。 通过酶联免疫吸附试验（ELISA）测定血清中RSV特异性IgG抗体（Ab），在脐带血中，连续样本3个月，并在配对的急性和恢复期样本。使用线性回归模型计算RSV-matAb下降率。研究了危险因素对脐带血滴度的影响。肯尼亚队列中matAb的半衰期计算为79天（95%置信限（CL）：76-81天）。97%的婴儿出生时携带RSV-matAb。随后在生命早期经历感染的婴儿与在前6个月内没有任何事件感染的婴儿相比，抗RSV Ab的脐带滴度显著较低（P = 0.011）。 RSV感染显示对RSV-matAb的衰减速率没有影响。母亲特异性RSV抗体在出生后迅速下降。然而，我们提供了RSV-matAb在最初6-7个月内预防严重疾病的证据。这表明通过RSV疫苗接种加强母体特异性Ab可能是一种值得考虑的有用策略。
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between these levels and protection from infection are poorly defined. A birth cohort (n = 635) in rural Kenya, was studied intensively to monitor infections and describe age-related serological characteristics. RSV specific IgG antibody (Ab) in serum was measured by the enzyme linked immunosorbent assay (ELISA) in cord blood, consecutive samples taken 3 monthly, and in paired acute and convalescent samples. A linear regression model was used to calculate the rate of RSV-matAb decline. The effect of risk factors on cord blood titres was investigated. The half-life of matAb in the Kenyan cohort was calculated to be 79 days (95% confidence limits (CL): 76–81 days). Ninety seven percent of infants were born with RSV-matAb. Infants who subsequently experienced an infection in early life had significantly lower cord titres of anti-RSV Ab in comparison to infants who did not have any incident infection in the first 6 months (P = 0.011). RSV infections were shown to have no effect on the rate of decay of RSV-matAb. Maternal-specific RSV Ab decline rapidly following birth. However, we provide evidence of protection against severe disease by RSV-matAb during the first 6–7 months. This suggests that boosting maternal-specific Ab by RSV vaccination may be a useful strategy to consider.
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