Lectin binding defines and differentiates M-cells in mouse small intestine and caecum
Lectin binding defines and differentiates M-cells in mouse small intestine and caecum
复制标题
凝集素结合定义并区分小鼠小肠和盲肠中的 M 细胞
DOI：
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发表时间：
1995
影响因子：
2.3
通讯作者：
B. Hirst
中科院分区：
文献类型：
--
作者：
M. Clark;M. Jepson;B. Hirst
通过将一组凝集素应用于整个固定的小鼠Peyer‘s和盲肠斑块来研究M细胞表面糖结合的表达。虽然大多数凝集素不能识别小鼠的M细胞，但欧洲卫矛凝集素对小鼠Peyer‘s和盲肠斑块中的M细胞表面进行了差异染色，而凝集素Ulex uropaeus II和Bandeiraea Simicifolia I Isolectin B4分别在Peyer’s和盲肠斑块毛囊相关上皮中识别出M细胞。这三种小鼠M细胞标记物不能识别大鼠和兔Peyer‘s Patch M细胞，尽管大黄卫矛和Ulex uropaeus II在兔盲肠圆顶周围对M细胞进行了差异染色。M细胞表面糖结合物表达的这些位点和物种相关的变化可能反映了当地的微生物种群，如果口服疫苗和药物通过M细胞的表面糖结合物靶向M细胞，将具有重要的意义。
M-cell surface glycoconjugate expression was investigated by applying a panel of lectins to whole fixed mouse Peyer's and caecal patches. While the majority of lectins failed to identify mouse M-cells, the lectinEuonymus europaeus differentially stained the surface of M-cells in both mouse Peyer's and caecal patches, and the lectinsUlex europaeus II andBandeiraea simplicifolia I isolectin B4 identified M-cells in the Peyer's and caecal patch follicle associated epithelium, respectively. These three mouse M-cell markers failed to identify rat and rabbit Peyer's patch M-cells, although bothEuonymus europaeus andUlex europaeus II differentially stained M-cells in the periphery of rabbit caecal patch domes. These site and species related variations in M-cell surface glycoconjugate expression may reflect the local microorganism populations and will have important implications if orally delivered vaccines and drugs are to be targeted to M-cells via their surface glycoconjugates.
DOI：
10.1152/ajpgi.1994.267.6.g1108
发表时间：
1994-12
期刊：
The American journal of physiology
影响因子：
--
作者：
Paul J. Giannasca;K. T. Giannasca;P. Falk;J. Gordon;Marian R. Neutra
通讯作者：
Paul J. Giannasca;K. T. Giannasca;P. Falk;J. Gordon;Marian R. Neutra
影响因子：
--
作者：
FALK, P;ROTH, KA;GORDON, JI
通讯作者：
GORDON, JI
微生物与肠道 M 细胞的相互作用：粘膜侵袭和分泌性免疫的诱导。
DOI：
--
发表时间：
1993
期刊：
Infectious agents and disease
影响因子：
--
作者：
Giannasca,PJ;Neutra,MR
通讯作者：
Neutra,MR