The association between brain volume, cortical brain infarcts, and physical frailty.
The association between brain volume, cortical brain infarcts, and physical frailty.
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DOI：
10.1016/j.neurobiolaging.2018.06.032
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发表时间：
2018-10
影响因子：
4.2
通讯作者：
BioCog Consortium
中科院分区：
文献类型：
--
作者：
Kant IMJ;de Bresser J;van Montfort SJT;Aarts E;Verlaan JJ;Zacharias N;Winterer G;Spies C;Slooter AJC;Hendrikse J;BioCog Consortium
身体虚弱是一种与年龄相关的储备减少的综合征，导致对生理应激源的脆弱性，并与负面结果相关。身体虚弱的潜在脑结构异常尚不清楚。我们研究了脑容量、皮质脑梗死和身体虚弱之间的关系。在这项多中心研究中，214名非痴呆参与者根据Fried虚弱表型分为虚弱（n = 32），虚弱前期（n = 107）或非虚弱（n = 75）。通过线性或逻辑回归分析研究了虚弱与脑体积和皮质脑梗死之间的关系。与非虚弱参与者相比，虚弱组的参与者显示出较低的总脑体积（-19.67 mL [95%置信区间-37.84至-1.50]）和较低的灰质体积（-12.19 mL [95%置信区间-23.84至-0.54]）。虚弱与皮质脑梗死相关[虚弱16% [n = 5]，虚弱前期11% [n = 12]，非虚弱3% [n = 2]]。因此，总脑体积和灰质体积的减少以及皮质脑梗死的增加似乎是身体虚弱表型的结构基底的一部分。
Physical frailty is an age-associated syndrome of decreased reserve leading to vulnerability to physiological stressors and associated with negative outcomes. The underlying structural brain abnormalities of physical frailty are unclear. We investigated the association between brain volume, cortical brain infarcts, and physical frailty. In this multicenter study, 214 nondemented participants were classified as frail (n = 32), prefrail (n = 107), or nonfrail (n = 75) based on the Fried frailty phenotype. The associations between frailty and brain volumes and cortical brain infarcts were investigated by linear or logistic regression analyses. Participants in the frail group showed a lower total brain volume (−19.67 mL [95% confidence interval −37.84 to −1.50]) and lower gray matter volume (−12.19 mL [95% confidence interval −23.84 to −0.54]) compared to nonfrail participants. Frailty was associated with cortical brain infarcts [frail 16% [n = 5], prefrail 11% [n = 12], and nonfrail 3% [n = 2]). Reduced total brain volume and gray matter volume and increased cortical brain infarcts seem therefore to be part of the structural substrate of the physical frailty phenotype.
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影响因子：
8.3
作者：
van Dijk, Ewoud J.;Prins, Niels D.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
DOI：
10.1093/gerona/56.3.m158
发表时间：
2001-03-01
影响因子：
5.1
作者：
Newman, AB;Gottdiener, JS;Fried, LP
通讯作者：
Fried, LP
影响因子：
4.2
作者：
Mak, Elijah;Su, Li;Williams, Guy B.;Watson, Rosie;Firbank, Michael;Blamire, Andrew M.;OBrien, John T.
通讯作者：
OBrien, John T.
DOI：
10.1093/gerona/gls190
发表时间：
2013-04-01
影响因子：
5.1
作者：
Savva, George M.;Donoghue, Orna A.;Kenny, Rose Anne
通讯作者：
Kenny, Rose Anne
影响因子：
6.7
作者：
Rolfson, Darryl B.;Majumdar, Sumit R.;Rockwood, Kenneth
通讯作者：
Rockwood, Kenneth